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Literature summary for 2.1.1.137 extracted from

  • Li, X.; Geng, Z.; Wang, S.; Song, X.; Hu, X.; Wang, Z.
    Functional evaluation of Asp76, 84, 102 and 150 in human arsenic(III) methyltransferase (hAS3MT) interacting with S-adenosylmethionine (2013), FEBS Lett., 587, 2232-2240.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) pLysS cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D102N inactive Homo sapiens
D102P inactive Homo sapiens
D150N the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
D150P inactive Homo sapiens
D76N inactive Homo sapiens
D76P inactive Homo sapiens
D84N inactive Homo sapiens
D84P inactive Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0032
-
arsenite wild type enzyme, at pH 7.0 and 37°C Homo sapiens
0.0044
-
arsenite mutant enzyme D150N, at pH 7.0 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + arsenite Homo sapiens
-
S-adenosyl-L-homocysteine + methylarsonate
-
?
S-adenosyl-L-methionine + methylarsonite Homo sapiens
-
S-adenosyl-L-homocysteine + dimethylarsinate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HBK9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + arsenite
-
Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
?
S-adenosyl-L-methionine + methylarsonite
-
Homo sapiens S-adenosyl-L-homocysteine + dimethylarsinate
-
?

Synonyms

Synonyms Comment Organism
arsenic(III) methyltransferase
-
Homo sapiens
AS3MT
-
Homo sapiens