Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 (DE3) pLysS cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D102N | inactive | Homo sapiens |
D102P | inactive | Homo sapiens |
D150N | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
D150P | inactive | Homo sapiens |
D76N | inactive | Homo sapiens |
D76P | inactive | Homo sapiens |
D84N | inactive | Homo sapiens |
D84P | inactive | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0032 | - |
arsenite | wild type enzyme, at pH 7.0 and 37°C | Homo sapiens | |
0.0044 | - |
arsenite | mutant enzyme D150N, at pH 7.0 and 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + arsenite | Homo sapiens | - |
S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
S-adenosyl-L-methionine + methylarsonite | Homo sapiens | - |
S-adenosyl-L-homocysteine + dimethylarsinate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HBK9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + arsenite | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
S-adenosyl-L-methionine + methylarsonite | - |
Homo sapiens | S-adenosyl-L-homocysteine + dimethylarsinate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arsenic(III) methyltransferase | - |
Homo sapiens |
AS3MT | - |
Homo sapiens |