Cloned (Comment) | Organism |
---|---|
after expression in COS-1 cells and correction for transfection efficiency, the Trp173 allozyme displays 31%, Thr287 350%, Ile306 4.8%, and Thr287/Ile306 6.2% of the activity of the wild type allozyme, with 20, 190, 4.4, and 7.9% of the level of wild-type immunoreactive protein, respectively | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0031 | - |
S-adenosyl-L-methionine | 37°C, pH 8.0, Trp173 allozyme | Homo sapiens | |
0.0045 | - |
arsenite | 37°C, pH 8.0, Thr287 allozyme | Homo sapiens | |
0.0046 | - |
S-adenosyl-L-methionine | 37°C, pH 8.0, wild-type enzyme | Homo sapiens | |
0.0089 | - |
arsenite | 37°C, pH 8.0, Trp173 allozyme | Homo sapiens | |
0.011 | - |
S-adenosyl-L-methionine | 37°C, pH 8.0, Thr287 allozyme | Homo sapiens | |
0.0118 | - |
arsenite | 37°C, pH 8.0, wild-type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + arsenite | Homo sapiens | AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans | S-adenosyl-L-homocysteine + methylarsonate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + arsenite | - |
Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? | |
S-adenosyl-L-methionine + arsenite | AS3MT may contribute to variation in arsenic metabolism and, perhaps, arsenic-dependent carcinogenesis in humans | Homo sapiens | S-adenosyl-L-homocysteine + methylarsonate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AS3MT | - |
Homo sapiens |