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Literature summary for 2.1.1.13 extracted from

  • Deng, X.; Guo, Y.; Tian, C.; Liu, J.; Wang, X.; Zhang, Z.
    Design, synthesis and activities of aziridine derivatives of N5-methyltetrahydrofolate against methionine synthase (2015), Chem. Res. Chin. Univ., 31, 742-745.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
N-(3-bromo-4-[[(1-[2-[(2,2-dimethylpropanoyl)amino]-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]aziridin-2-yl)methyl](methyl)amino]benzoyl)-L-glutamic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00415
-
pH 7.2, 37°C Homo sapiens N-(3-bromo-4-[[(1-[2-[(2,2-dimethylpropanoyl)amino]-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]aziridin-2-yl)methyl](methyl)amino]benzoyl)-L-glutamic acid