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Literature summary for 2.1.1.13 extracted from

  • Tang, C.; Zhang, Z.; Xu, B.; Li, M.; Liu, J.; Cui, J.
    Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro (2008), Anticancer Drugs, 19, 697-704.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ZL-031 i.e. diethyl N-[4-[(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino]3-bromo-benzoyl]L-glutamate Homo sapiens
ZL-033 i.e. N-[4-[(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino]3-bromo-benzoyl]L-glutamic acid Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Homo sapiens tetrahydropteroylmonoglutamate + L-methionine
-
?

Synonyms

Synonyms Comment Organism
5-methyltetrahydrofolate-homocysteine methyltransferase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
at 37°C Homo sapiens ZL-033
0.01
-
at 37°C Homo sapiens ZL-031