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Literature summary for 2.1.1.13 extracted from
- Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: binding of the folate substrate to the enzyme (1972), Arch. Biochem. Biophys., 151, 401-413.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.035 | - |
5-methyltetrahydrofolate | - |
Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
B | - |
| Escherichia coli B / ATCC 11303 | - |
B | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine | mechanism | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | binding of the folate substrate | Escherichia coli | ? | - |
? | |
| additional information | binding of the folate substrate | Escherichia coli B / ATCC 11303 | ? | - |
? | |
| N5-methyltetrahydrofolate + L-homocysteine | - |
Escherichia coli | tetrahydrofolate + L-methionine | - |
? | |
| N5-methyltetrahydrofolate + L-homocysteine | - |
Escherichia coli B / ATCC 11303 | tetrahydrofolate + L-methionine | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| vitamin B12 | enzyme contains a derivative of vitamin B12 as prosthetic group | Escherichia coli | |
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