Literature summary for 2.1.1.104 extracted from

Sekhar Pagadala, N.; Arha, M.; Reddy, P.S.; Kumar, R.; Sirisha, V.L.; Prashant, S.; Janardhan Reddy, K.; Khan, B.; Rawal, S.K.; Kavi Kishor, P.B.
Phylogenetic analysis, homology modelling, molecular dynamics and docking studies of caffeoyl-CoA-O-methyl transferase (CCoAOMT 1 and 2) isoforms isolated from subabul (Leucaena leucocephala) (2009), J. Mol. Model., 15, 203-221.

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Cloned(Commentary)

Cloned (Comment)	Organism
isozyme CCoAOMT 1, DNA and amino acid sequence determination and analysis, phylogenetic analysis	Leucaena leucocephala
isozyme CCoAOMT 2, DNA and amino acid sequence determination and analysis, phylogenetic analysis	Leucaena leucocephala

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA	Leucaena leucocephala	-	S-adenosyl-L-homocysteine + sinapoyl-CoA	-	?
S-adenosyl-L-methionine + caffeoyl-CoA	Leucaena leucocephala	-	S-adenosyl-L-homocysteine + feruloyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Leucaena leucocephala	Q0N3X0	CCoAOMT 2; i.e. Leucaena glauca, isozyme CCoAOMT 2	-
Leucaena leucocephala	Q0N3X1	CCoAOMT 1; i.e. Leucaena glauca, isozyme CCoAOMT 1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	CoA and caffeoyl CoA are binding with high affinity to the enzymes in the presence and absence of S-adenosyl-L-methionine, thereby with higher affinity to isozyme CCoAOMT2 than CCoAOMT1, molecular dynamics, simulations, and docking analysis, overview. Conserved active site residues Met58, Thr60, Val63, Glu82, Gly84, Ser90, Asp160, Asp162, Thr169, Asn191 and Arg203 in CCoAOMT1 and CCoAOMT2 enzymes create the positive charge to balance the negatively charged caffeoyl CoA and play an important role in maintaining a functional conformation and are directly involved in donor substrate binding	Leucaena leucocephala	?	-	?
S-adenosyl-L-methionine + 5-hydroxy-feruloyl-CoA	-	Leucaena leucocephala	S-adenosyl-L-homocysteine + sinapoyl-CoA	-	?
S-adenosyl-L-methionine + caffeoyl-CoA	-	Leucaena leucocephala	S-adenosyl-L-homocysteine + feruloyl-CoA	-	?

Subunits

Subunits	Comment	Organism
More	isozyme CCoAOMT 1, three dimensional structure building by computational methods, overview	Leucaena leucocephala
More	isozyme CCoAOMT 2, three dimensional structure building by computational methods, overview	Leucaena leucocephala

Synonyms

Synonyms	Comment	Organism
caffeoyl-CoA-O-methyl transferase 1	-	Leucaena leucocephala
caffeoyl-CoA-O-methyl transferase 2	-	Leucaena leucocephala
CCoAOMT 1	-	Leucaena leucocephala
CCoAOMT 2	-	Leucaena leucocephala

Cofactor

Cofactor	Comment	Organism	Structure
S-adenosyl-L-methionine	-	Leucaena leucocephala

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in lignin biosynthesis especially in the formation of cell wall ferulic esters of plants. It plays a pivotal role in the methylation of the 3-hydroxyl group of caffeoyl CoA	Leucaena leucocephala

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Release 2023.1 (January 2023)