Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Plasmodium knowlesi |
expressed in Escherichia coli BL21(DE3) cells | Plasmodium vivax |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 100 mM Na-acetate (pH 5.0), and 20% (w/v) PEG 3350 | Plasmodium knowlesi |
sitting drop vapor diffusion method, using 200 mM NH4-formate and 20% (w/v) PEG 3350 | Plasmodium vivax |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amodiaquine | - |
Plasmodium knowlesi | |
amodiaquine | - |
Plasmodium vivax | |
Chloroquine | - |
Plasmodium knowlesi | |
Chloroquine | - |
Plasmodium vivax | |
NSC158011 | - |
Plasmodium knowlesi | |
NSC158011 | - |
Plasmodium vivax |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
Ethanolamine phosphate | at pH 8.6 and 37°C | Plasmodium knowlesi | |
0.21 | - |
Ethanolamine phosphate | at pH 8.6 and 37°C | Plasmodium vivax | |
0.23 | - |
S-adenosyl-L-methionine | at pH 8.6 and 37°C | Plasmodium vivax | |
0.27 | - |
S-adenosyl-L-methionine | at pH 8.6 and 37°C | Plasmodium knowlesi |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
31000 | - |
x * 31000, SDS-PAGE | Plasmodium knowlesi |
31000 | - |
x * 31000, SDS-PAGE | Plasmodium vivax |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + ethanolamine phosphate | Plasmodium knowlesi | - |
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate | - |
? | |
S-adenosyl-L-methionine + ethanolamine phosphate | Plasmodium vivax | - |
S-adenosyl-L-homocysteine + N-methylethanolamine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium knowlesi | B3L8G9 | - |
- |
Plasmodium vivax | A5K867 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel HisTrap column chromatography and Superdex 75PG gel filtration | Plasmodium knowlesi |
nickel HisTrap column chromatography and Superdex 75PG gel filtration | Plasmodium vivax |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + ethanolamine phosphate | - |
Plasmodium knowlesi | S-adenosyl-L-homocysteine + N-methylethanolamine phosphate | - |
? | |
S-adenosyl-L-methionine + ethanolamine phosphate | - |
Plasmodium vivax | S-adenosyl-L-homocysteine + N-methylethanolamine phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 31000, SDS-PAGE | Plasmodium knowlesi |
? | x * 31000, SDS-PAGE | Plasmodium vivax |
Synonyms | Comment | Organism |
---|---|---|
phosphoethanolamine methyltransferase | - |
Plasmodium knowlesi |
phosphoethanolamine methyltransferase | - |
Plasmodium vivax |
PMT | - |
Plasmodium knowlesi |
PMT | - |
Plasmodium vivax |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.05 | - |
at pH 8.6 and 37°C | Plasmodium knowlesi | NSC158011 | |
0.099 | - |
at pH 8.6 and 37°C | Plasmodium vivax | NSC158011 | |
0.146 | - |
at pH 8.6 and 37°C | Plasmodium knowlesi | Chloroquine | |
0.146 | - |
at pH 8.6 and 37°C | Plasmodium vivax | Chloroquine | |
0.22 | - |
at pH 8.6 and 37°C | Plasmodium vivax | amodiaquine | |
0.398 | - |
at pH 8.6 and 37°C | Plasmodium knowlesi | amodiaquine |