Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp) | - |
Saccharomyces cerevisiae | |
biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp) | - |
Saccharomyces cerevisiae | |
biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp) | - |
Saccharomyces cerevisiae | |
biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp) | - |
Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0034 | - |
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine | at pH 7.5 and 25°C | Homo sapiens | |
0.0051 | - |
biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp) | at pH 7.5 and 25°C | Homo sapiens | |
0.0059 | - |
4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine | at pH 7.5 and 25°C | Homo sapiens | |
0.0061 | - |
biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp) | IC50 above 0.1 mM, at pH 7.5 and 25°C | Homo sapiens | |
0.0103 | - |
N-acetyl-S-farnesyl-L-cysteine | at pH 7.5 and 25°C | Saccharomyces cerevisiae | |
0.0146 | - |
biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp) | IC50 above 0.1 mM, at pH 7.5 and 25°C | Homo sapiens | |
0.015 | - |
biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp) | at pH 7.5 and 25°C | Homo sapiens | |
0.0159 | - |
N-acetyl-S-farnesyl-L-cysteine | at pH 7.5 and 25°C | Homo sapiens | |
0.0179 | - |
4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine | at pH 7.5 and 25°C | Saccharomyces cerevisiae | |
0.0183 | - |
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine | at pH 7.5 and 25°C | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
endoplasmic reticulum membrane | - |
Saccharomyces cerevisiae | 5789 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
x * 26000, SDS-PAGE | Saccharomyces cerevisiae |
33000 | - |
x * 33000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | Saccharomyces cerevisiae | - |
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine | Homo sapiens | - |
S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine | Saccharomyces cerevisiae | - |
S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine | Saccharomyces cerevisiae | - |
S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp) | - |
Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp) | - |
Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp) | - |
Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp) | - |
Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine | - |
Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + N-acetyl-S-farnesyl-L-cysteine | - |
Saccharomyces cerevisiae | ? | - |
? | |
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + Ras protein C-terminal S-farnesyl-L-cysteine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + Ras protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + ? | - |
? | |
S-adenosyl-L-methionine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine | - |
Saccharomyces cerevisiae | S-adenosyl-L-homocysteine + yeast a-factor mating pheromone C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26000, SDS-PAGE | Saccharomyces cerevisiae |
? | x * 33000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Homo sapiens |
Icmt | - |
Saccharomyces cerevisiae |
isoprenylcysteine carboxyl methyltransferase | - |
Homo sapiens |
isoprenylcysteine carboxyl methyltransferase | - |
Saccharomyces cerevisiae |
Ste14p | - |
Saccharomyces cerevisiae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0137 | - |
at pH 7.5 and 25°C | Saccharomyces cerevisiae | biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp) | |
0.0257 | - |
at pH 7.5 and 25°C | Saccharomyces cerevisiae | biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp) | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 25°C | Saccharomyces cerevisiae | biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp) | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 25°C | Saccharomyces cerevisiae | biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp) |