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Literature summary for 2.1.1.100 extracted from

  • Huizinga, D.H.; Omosegbon, O.; Omery, B.; Crowell, D.N.
    Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis (2008), Plant Cell, 20, 2714-2728.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.100

Application

Application Comment Organism
biotechnology the enzyme is a target for metabolic engineering of crop species for drought tolerance by targeted alterations in isoprenylcysteine methylation Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment) Organism
the ICMT isozyme is encoded by the STE14A ICMT gene Arabidopsis thaliana
the ICMT isozyme is encoded by the STE14B ICMT gene Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information transgenic plants overproducing ICME exhibit abscisic acid hypersensitivity in stomatal closure and seed germination assays. Induction leads to demethylation and inactivation of isoprenylated negative regulators of abscisic acid signaling Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana the ICMT isozyme catalyzes the methylation of C-terminal isoprenylcysteines ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 the ICMT isozyme is encoded by the STE14A ICMT gene
-
Arabidopsis thaliana Q93W54 ICMT isozymes is encoded by the STE14B ICMT gene
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the ICMT isozyme catalyzes the methylation of C-terminal isoprenylcysteines Arabidopsis thaliana ?
-
 ?
additional information isozyme substrate specificity, no activity with N-acetyl-S-trans-geranyl-L-cysteine, overview Arabidopsis thaliana ?
-
 ?
S-adenosyl-L-methionine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine
-
 Arabidopsis thaliana S-adenosyl-L-homocysteine + N-acetyl-S-all trans-geranylgeranyl-L-cysteine methyl ester
-
 ?
S-adenosyl-L-methionine + N-acetyl-S-trans,trans-farnesyl-L-cysteine
-
 Arabidopsis thaliana S-adenosyl-L-homocysteine + N-acetyl-S-trans,trans-farnesyl-L-cysteine methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
Icmt
-
 Arabidopsis thaliana
isoprenylcysteine methylesterase
-
 Arabidopsis thaliana
STE14A
-
 Arabidopsis thaliana
STE14B
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana abscisic acid promotes abscisic acid responsiveness of plant cells via induction of ICME expression up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the farnesyl metabolism, overview Arabidopsis thaliana
physiological function isoprenylcysteine methylation and demethylation positively regulate abscisic acid signaling in Arabidopsis thaliana via feedback mechanism involving demethylation and inactivation of isoprenylated negative regulators of abscisic acid signaling Arabidopsis thaliana