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Literature summary for 2.1.1.100 extracted from

  • Buchanan, M.S.; Carroll, A.R.; Fechner, G.A.; Boyle, A.; Simpson, M.; Addepalli, R.; Avery, V.M.; Forster, P.I.; Guymer, G.P.; Cheung, T.; Chen, H.; Quinn, R.J.
    Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx (2008), Phytochemistry, 69, 1886-1889.
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme is a target for anticancer drug design Homo sapiens
pharmacology the enzyme is a target in anticancer therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-glabrol structure determination, overview Homo sapiens
2'-methoxy-3',3''-diprenyl-licodione isolated from Hovea parvicalyx, collected in Australia, structure determination, overview Homo sapiens
2'-methoxy-3'-prenyllicodione isolated from Hovea parvicalyx, collected in Australia, structure determination, overview Homo sapiens
aplysamine 6
-
Homo sapiens
spermatinamine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
Icmt
-
Homo sapiens
isoprenylcysteine carboxyl methyltransferase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.017
-
-
Homo sapiens 2'-methoxy-3',3''-diprenyl-licodione
0.025
-
-
Homo sapiens (S)-glabrol
0.03
-
-
Homo sapiens 2'-methoxy-3'-prenyllicodione