Literature summary for 2.1.1.1 extracted from

Win, K.T.; Lee, S.W.; Huang, H.Y.; Lin, L.C.; Lin, C.Y.; Hsing, C.H.; Chen, L.T.; Li, C.F.
Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma (2013), Tumour Biol., 34, 3923-3931.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene NNMT, quantitative enzyme expression anaysis in 124 nasopharyngeal carcinoma samples, analysis of associations between NNMT and pAktSer473 expression and other important clinicopathologic variables, overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	forced NNMT overexpression strongly induces the invasive capacity in human embryonic kidney 293 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene NNMT	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	the enzyme is overexpressed in many human cancers and is associated with poor prognosis	Homo sapiens	-
nasopharyngeal carcinoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
NNMT	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the NNMT gene is differentially upregulated in nasopharyngeal cancer tissues	up

General Information

General Information	Comment	Organism
malfunction	nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma	Homo sapiens
metabolism	NNMTexpression is significantly positively associated with pAkt/protein kinase B expression	Homo sapiens
physiological function	the enzyme is overexpressed in many human cancers and is associated with poor prognosis. Enzyme NNMT might play a significant role in tumor progression and shorter survival time in patients with nasopharyngeal carcinoma, and it might promote the activation of MMP-2 via a pathway that sequentially involves pAkt signaling pathway	Homo sapiens

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Release 2023.1 (January 2023)