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Literature summary for 2.1.1.1 extracted from

  • Sartini, D.; Morganti, S.; Guidi, E.; Rubini, C.; Zizzi, A.; Giuliante, R.; Pozzi, V.; Emanuelli, M.
    Nicotinamide N-methyltransferase in non-small cell lung cancer: promising results for targeted anti-cancer therapy (2013), Cell Biochem. Biophys., 67, 865-873.
    View publication on PubMed
Search for more literature for 2.1.1.1

Application

Application Comment Organism
drug development the enzyme might be a good molecular target for lung cancer therapy Homo sapiens
pharmacology the enzyme might be a good molecular target for lung cancer therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR enzyme expression analysis in non-smalll cell lung cancer samples Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide Homo sapiens
-
 S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
additional information quantitative real-time PCR enzyme expression analysis Homo sapiens
-
non-small cell lung cancer cell the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 quantitative enzyme activity analysis in 25 non-smalll cell lung cancer samples Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
NNMT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction shRNA-mediated gene silencing of NNMT leads to a significntl inhibition of cell proliferation and colony formation ability, downregulation of the enzyme significantly reduces the tumorigenicity of A-549 cells Homo sapiens
physiological function role of nicotinamide N-methyltransferase in non-small cell lung cancer Homo sapiens