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Literature summary for 1.8.98.2 extracted from

  • Noh, Y.H.; Baek, J.Y.; Jeong, W.; Rhee, S.G.; Chang, T.S.
    Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III (2009), J. Biol. Chem., 284, 8470-8477.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
the vectors pcDNA3 and pFLAG-CMV2 are used, a leader sequence is cloned into the N-terminus coding region of Srx Homo sapiens

Protein Variants

Protein Variants Comment Organism
C99S catalytic cysteine mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic Srx is translocated into the mitochondria under oxidative conditions Homo sapiens 5829
-
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH Homo sapiens
-
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Synonyms

Synonyms Comment Organism
Srx
-
Homo sapiens
sulfiredoxin
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens