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Literature summary for 1.8.98.2 extracted from

  • Roussel, X.; Kriznik, A.; Richard, C.; Rahuel-Clermont, S.; Branlant, G.
    The catalytic mechanism of Sulfiredoxin from Saccharomyces cerevisiae passes through an oxidized disulfide Sulfiredoxin intermediate that is reduced by thioredoxin (2009), J. Biol. Chem., 284, 33048-33055.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
C106A mutant, constructed to address questions regarding the catalytic mechanisms and the role of the cysteine residues Saccharomyces cerevisiae
C48A mutant, constructed to address questions regarding the catalytic mechanisms and the role of the cysteine residues Saccharomyces cerevisiae
C48A/C106A mutant, constructed to address questions regarding the catalytic mechanisms and the role of the cysteine residues Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
15000
-
Srx monomer, determined by SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH Saccharomyces cerevisiae
-
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
Saccharomyces cerevisiae peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Synonyms

Synonyms Comment Organism
Srx
-
Saccharomyces cerevisiae
sulfiredoxin
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Saccharomyces cerevisiae
dithiothreitol
-
Saccharomyces cerevisiae
thioredoxin
-
Saccharomyces cerevisiae