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Literature summary for 1.8.98.2 extracted from

  • Singh, A.; Ling, G.; Suhasini, A.N.; Zhang, P.; Yamamoto, M.; Navas-Acien, A.; Cosgrove, G.; Tuder, R.M.; Kensler, T.W.; Watson, W.H.; Biswal, S.
    Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs (2009), Free Radic. Biol. Med., 46, 376-386.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.98.2

Application

Application Comment Organism
medicine oxidative stress results in protein oxidation and is involved in the pathogenesis of lung diseases such as chronic obstructive pulmonary disorder, COPD, in lungs from COPD patients the expression of Srx1 is dramatically decreased Mus musculus
medicine oxidative stress results in protein oxidation and is involved in the pathogenesis of lung diseases such as chronic obstructive pulmonary disorder, COPD, in lungs from COPD patients the expression of Srx1 is dramatically decreased Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the 5' flanking region of the human Srx1 promoter region, -3664 - +19, is ligated into the vector pCR2.1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RNAi
-
 Homo sapiens
RNAi
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation ?
-
 ?
additional information Homo sapiens catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
BEAS-2B cell
-
 Homo sapiens
-
lung
-
 Mus musculus
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation Mus musculus ?
-
 ?
additional information catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
neoplastic progression 3
-
 Mus musculus
neoplastic progression 3
-
 Homo sapiens
Srx1
-
 Mus musculus
Srx1
-
 Homo sapiens
sulfiredoxin-1
-
 Mus musculus
sulfiredoxin-1
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus disruption of Nrf2 signaling down-regulates the expression of Srx1 down
Homo sapiens disruption of Nrf2 signaling down-regulates the expression of Srx1 down
Mus musculus Nrf2, nuclear factor erythroid-2-related factor, up-regulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs up
Homo sapiens Nrf2, nuclear factor erythroid-2-related factor, up-regulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs up