Application | Comment | Organism |
---|---|---|
medicine | oxidative stress results in protein oxidation and is involved in the pathogenesis of lung diseases such as chronic obstructive pulmonary disorder, COPD, in lungs from COPD patients the expression of Srx1 is dramatically decreased | Mus musculus |
medicine | oxidative stress results in protein oxidation and is involved in the pathogenesis of lung diseases such as chronic obstructive pulmonary disorder, COPD, in lungs from COPD patients the expression of Srx1 is dramatically decreased | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
the 5' flanking region of the human Srx1 promoter region, -3664 - +19, is ligated into the vector pCR2.1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNAi | - |
Homo sapiens | |
RNAi | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation | ? | - |
? | |
additional information | Homo sapiens | catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
BEAS-2B cell | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation | Mus musculus | ? | - |
? | |
additional information | catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neoplastic progression 3 | - |
Mus musculus |
neoplastic progression 3 | - |
Homo sapiens |
Srx1 | - |
Mus musculus |
Srx1 | - |
Homo sapiens |
sulfiredoxin-1 | - |
Mus musculus |
sulfiredoxin-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | disruption of Nrf2 signaling down-regulates the expression of Srx1 | down |
Homo sapiens | disruption of Nrf2 signaling down-regulates the expression of Srx1 | down |
Mus musculus | Nrf2, nuclear factor erythroid-2-related factor, up-regulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs | up |
Homo sapiens | Nrf2, nuclear factor erythroid-2-related factor, up-regulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs | up |