Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
periplasm | - |
Escherichia coli | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
21100 | - |
DsbA gene product | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSH + protein disulfide | Escherichia coli | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | GSSG + protein-dithiol | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Haemophilus influenzae | - |
DsbA homologous | - |
Haemophilus influenzae | - |
Por gene | - |
Haemophilus influenzae DsbA homologous | - |
DsbA homologous | - |
Vibrio cholerae serotype O1 | - |
tcpG gene | - |
Vibrio cholerae serotype O1 | - |
DsbA homologous | - |
Vibrio cholerae serotype O1 DsbA homologous | - |
DsbA homologous | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol | C-X-X-C motif in active site for disulfide bonding, either oxidizing, reducing and isomerising activity | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSH + protein disulfide | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | Escherichia coli | GSSG + protein-dithiol | - |
r | |
additional information | DsbB protein re-oxidizes the reduced DsbA protein | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | DsbA protein family including periplasmic protein disulfide: thiol oxidoreductases with high homology in amino acid sequences | Escherichia coli |