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Literature summary for 1.8.4.2 extracted from

  • Morin, J.E.; Carmichael, C.F.; Dixon, J.E.
    Characterization, kinetics and comparative properties of thiol:protein disulfide oxidoreductase (1978), Arch. Biochem. Biophys., 189, 354-363.
    View publication on PubMed

General Stability

General Stability Organism
EDTA stabilizes during purification Bos taurus
GSH, 10 mM, enhances heat stability Bos taurus
insulin, 0.087 mM, decreases heat stability Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ slight Bos taurus
Cu2+
-
Bos taurus
deoxycholate
-
Bos taurus
Hg2+
-
Bos taurus
Mg2+ slight inhibition Bos taurus
Zn2+ slight inhibition Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Bos taurus

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-mercaptoethanol + protein disulfide
-
Bos taurus 2-mercaptoethanol disulfide + protein-dithiol
-
?
dithiothreitol + protein disulfide
-
Bos taurus ?
-
?
GSH + insulin
-
Bos taurus GSSG + reduced insulin chain A and B
-
?
GSH + oxytoxin
-
Bos taurus ?
-
?
GSH + protein disulfide
-
Bos taurus GSSG + protein-dithiol
-
?
GSH + vasopressin
-
Bos taurus ?
-
?
GSH + vasotocin
-
Bos taurus ?
-
?
GSSG + reduced ribonuclease
-
Bos taurus GSH + oxidized ribonuclease
-
?
L-cysteine + protein disulfide
-
Bos taurus cystine + protein-dithiol
-
?
additional information enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease Bos taurus ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
30 min, 50% loss of activity Bos taurus
65
-
30 min, 90% loss of activity Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
6.2 10.2 pH 6.2: about 10% of activity maximum, pH 10.2: about 20% of activity maximum Bos taurus