Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EDTA | 5 mM: inhibition | Rattus norvegicus |
General Stability | Organism |
---|---|
EDTA 5mM, 37°C, phosphate buffer, total loss of activity within 30-60 min, can partially be prevented by NADPH | Rattus norvegicus |
metal ions required for activity and maintenance of the proper conformation of the enzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cysteine | at high concentration | Rattus norvegicus | |
EDTA | 50% inhibition at 5 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Rattus norvegicus | |
0.13 | - |
reduced dithiothreitol | - |
Rattus norvegicus | |
0.14 | - |
dihydrolipoamide | - |
Rattus norvegicus | |
0.2 | - |
2-mercaptoethanol | - |
Rattus norvegicus | |
0.2 | - |
dihydrolipoate | - |
Rattus norvegicus | |
0.27 | - |
cysteine | - |
Rattus norvegicus | |
0.31 | - |
GSH | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cs+ | 0.3 M: activates | Rattus norvegicus | |
Mn2+ | 1 mM: activates | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-mercaptoethanol + protein disulfide | - |
Rattus norvegicus | 2-mercaptoethanol disulfide + protein-dithiol | - |
? | |
dihydrolipoamide + protein disulfide | - |
Rattus norvegicus | ? | - |
? | |
dihydrolipoate + protein disulfide | - |
Rattus norvegicus | ? | - |
? | |
dithiothreitol + protein disulfide | - |
Rattus norvegicus | ? | - |
? | |
GSH + protein disulfide | - |
Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
L-cysteine + protein disulfide | - |
Rattus norvegicus | cystine + protein-dithiol | - |
? | |
reduced dithiothreitol + NADP+ | - |
Rattus norvegicus | oxidized dithiothreitol + NADPH + H+ | - |
r |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
phosphate buffer, 5 h without loss of activity | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
GSH | Rattus norvegicus |
9 | - |
DL-dihydrolipoate | Rattus norvegicus |