Application | Comment | Organism |
---|---|---|
synthesis | enzyme can be useful in the development and action of anti-cancer and anti-inflammation drugs | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | enzyme form Mem-R,S-Msr | Escherichia coli | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (S)-sulfoxide + NADPH + H+ | Escherichia coli | membrane-bound enzyme form Mem-R,S-Msr | L-methionine + NADP+ + H2O | - |
? | |
additional information | Escherichia coli | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | ? | - |
? | |
sulindac + NADPH | Escherichia coli | activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr | sulindac sulfide + NADP+ + H2O | activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli | - |
isozyme Mem-R,S-Msr, bifunctional enzyme | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00009 | - |
enzyme form Mem-R,S-Msr, substrate sulindac | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (S)-sulfoxide + NADPH + H+ | membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | L-methionine + NADP+ + H2O | - |
? | |
L-methionine sulfoxide enkephalin + NADPH | membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | L-methionine enkephalin + NADP+ + H2O | - |
? | |
L-methionine-(S)-S-oxide + thioredoxin | - |
Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Escherichia coli | ? | - |
? | |
additional information | substrate specificity, overview, Mem-R,S-Msr can also catalyze the reduction of L-methionine (R)-sulfoxide, EC 1.8.4.14, enzyme reduces oxidized methionine residues of the ribosomal protein L12, which becomes reversibly inactivated and forms monomers instead of dimers upon oxidation | Escherichia coli | ? | - |
? | |
additional information | no activity with peptide-L-methionine-(S)-S-oxide | Escherichia coli | ? | - |
? | |
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin | membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
sulindac + NADPH | activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | sulindac sulfide + NADP+ + H2O | activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity | ? | |
sulindac + NADPH | activity with membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | sulindac sulfide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
fSMsr | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no activity with DTT as cofactor by membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | |
NADPH | membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli |