Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.4.12 extracted from

  • Moskovitz, J.
    Roles of methionine suldfoxide reductases in antioxidant defense, protein regulation and survival (2005), Curr. Pharm. Des., 11, 1451-1457.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information heat shock, dehydration, and reactive oxygen species like H2O2 induce the expression of MsrB Arabidopsis thaliana
additional information starvation induces MsrB expression, also heat treatment and methylmethanesulfonate induce the enzyme Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information cells lacking MsrB show increased sensitivity to oxidative damage, and methionine-(R)-S-oxide accumulation Arabidopsis thaliana
additional information construction of MsrB null mutant and of overexpressing strains, phenotypes, overview Mus musculus
additional information yeast cells lacking MsrB show increased sensitivity to oxidative damage, and methionine-(R)-S-oxide accumulation Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isozyme MsrB1 Mus musculus 5829
-
cytosol isozyme MsrB1 Homo sapiens 5829
-
endoplasmic reticulum isozyme MsrB3 Mus musculus 5783
-
endoplasmic reticulum isozyme MsrB3 Homo sapiens 5783
-
intracellular
-
Saccharomyces cerevisiae 5622
-
intracellular
-
Arabidopsis thaliana 5622
-
mitochondrion isozymes MsrB2 and MsrB3 Mus musculus 5739
-
mitochondrion isozymes MsrB2 and MsrB3 Homo sapiens 5739
-
additional information subcellular targeting is determined by alternative splicing Mus musculus
-
-
additional information subcellular targeting is determined by alternative splicing Homo sapiens
-
-
nucleus isozyme MsrB1 Mus musculus 5634
-
nucleus isozyme MsrB1 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB Mus musculus
additional information the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB Homo sapiens
additional information the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB Saccharomyces cerevisiae
additional information the major isozyme of MsrB, MsrB1, is a selenoprotein, selenium affects the expression of MsrB Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine-(R)-S-oxide + thioredoxin Mus musculus
-
L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin Saccharomyces cerevisiae
-
L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin Arabidopsis thaliana substrate in vivo is e.g. the small heat shock protein Hsp-21 which loses its chaperone-like activity upon methionine oxidation L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin Homo sapiens substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview L-methionine + thioredoxin disulfide + H2O
-
?
additional information Arabidopsis thaliana roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview ?
-
?
additional information Mus musculus roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
?
additional information Saccharomyces cerevisiae roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, regulation of MsrB expression, overview ?
-
?
additional information Homo sapiens roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
isozymes MsrB1-3
-
Homo sapiens
-
isozymes MsrB1-3
-
Mus musculus
-
isozymes MsrB1-3
-
Saccharomyces cerevisiae
-
isozymes MsrB1-3
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine-(R)-S-oxide + thioredoxin
-
Mus musculus L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin
-
Saccharomyces cerevisiae L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction Mus musculus L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction Saccharomyces cerevisiae L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction Arabidopsis thaliana L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin substrate in vivo is e.g. the small heat shock protein Hsp-21 which loses its chaperone-like activity upon methionine oxidation Arabidopsis thaliana L-methionine + thioredoxin disulfide + H2O
-
?
L-methionine-(R)-S-oxide + thioredoxin substrates are HIV-2, which is inactivated by oxidation of its methionine residues M76 and M95, the potassium channel of the brain, the inhibitor IkappaB-alpha, or calmodulin, overview Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview Arabidopsis thaliana ?
-
?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Mus musculus ?
-
?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, regulation of MsrB expression, overview Saccharomyces cerevisiae ?
-
?
additional information roles of methionine sulfoxide reductases in antioxidant defense, protein regulation via alternating it between active and inactive form, and survival, MsrB protects cells from the cytotoxic effects of reactive oxygen species, ROS, overview, the enzyme is involved in age-related diseases such as Alzheimer's or Parkinson's diseases as well as in diseases caused by prions, mechanism, overview, enzyme involvement in protein repair and associated factors, protein regulation pathway, overview Homo sapiens ?
-
?
additional information the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO Mus musculus ?
-
?
additional information the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO Homo sapiens ?
-
?
additional information the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO Saccharomyces cerevisiae ?
-
?
additional information the enzyme utilizes free and protein-bound methionine-(R)-S-oxide as substrate, but prefers the latter, methionine oxidation inactivates the proteins showing equal distribution of S-MetO and R-MetO Arabidopsis thaliana ?
-
?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase B
-
Mus musculus
methionine sulfoxide reductase B
-
Homo sapiens
methionine sulfoxide reductase B
-
Saccharomyces cerevisiae
methionine sulfoxide reductase B
-
Arabidopsis thaliana
More the enzyme belongs to the Msr family of enzymes Mus musculus
More the enzyme belongs to the Msr family of enzymes Homo sapiens
More the enzyme belongs to the Msr family of enzymes Saccharomyces cerevisiae
More the enzyme belongs to the Msr family of enzymes Arabidopsis thaliana
MsrB
-
Mus musculus
MsrB
-
Homo sapiens
MsrB
-
Saccharomyces cerevisiae
MsrB
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
Mus musculus
thioredoxin
-
Homo sapiens
thioredoxin
-
Saccharomyces cerevisiae
thioredoxin
-
Arabidopsis thaliana