Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Bos taurus | 16020 | - |
membrane | membrane-associated enzyme MsrB | Escherichia coli | 16020 | - |
microsome | - |
Escherichia coli | - |
- |
microsome | - |
Bos taurus | - |
- |
mitochondrion | - |
Escherichia coli | 5739 | - |
mitochondrion | - |
Bos taurus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sulindac + thioredoxin | Bos taurus | - |
sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
sulindac + thioredoxin | Escherichia coli | activation of the antiinflammatory drug with anti-tumorigenic activity, which acts via inhibition of cyclooxygenases 1 and 2 | sulindac sulfide + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calf | - |
Escherichia coli | - |
enzyme forms MsrB, and other enzyme forms, e.g. Mem-R,S-Msr, overview | - |
Purification (Comment) | Organism |
---|---|
partially, cell fragmentation | Bos taurus |
recombinant MsrB | Escherichia coli |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
kidney | highest sulindac reductase activity | Bos taurus | - |
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000085 | - |
enzyme form Mem-R,S-Msr | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate specificity of enzyme forms with R-form of free and protein-bound methionine sulfoxide, overview | Escherichia coli | ? | - |
? | |
sulindac + thioredoxin | - |
Bos taurus | sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
sulindac + thioredoxin | activation of the antiinflammatory drug with anti-tumorigenic activity, which acts via inhibition of cyclooxygenases 1 and 2 | Escherichia coli | sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
sulindac + thioredoxin | highest activity by a membrane bound enzyme form Mem-R,S-Msr, which preferentially reduces the R-substrate form, no activity by enzyme forms fRMsr, fSMsr, low activity by enzyme forms MsrB | Escherichia coli | sulindac sulfide + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase | - |
Bos taurus |
sulindac reductase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Escherichia coli |
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Escherichia coli |
7.4 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Escherichia coli | |
thioredoxin | - |
Bos taurus |