Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase A | - |
Mus musculus |
MsrA | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme-deficient mice are more susceptible to kidney ischemia/reperfusion injury than wild type mice. Deletion of the enzyme enhances renal functional and morphological impairments, congestion, inflammatory responses, and oxidative stress under ischemia/reperfusion conditions | Mus musculus |
metabolism | the enzyme participates in regulating methionine metabolism and the trans-sulfuration pathway under normal and ischemia/reperfusion conditions | Mus musculus |
physiological function | the enzyme protects the kidney against ischemia/reperfusion injury. This protection is associated with reduced oxidative stress and inflammatory responses. The enzyme regulates H2S production during ischemia/reperfusion by modulating the expression and activity of the cystathionine-beta-synthase and cystathionine-gamma-lyase enzymes | Mus musculus |