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Literature summary for 1.8.4.11 extracted from

  • Soriani, F.M.; Kress, M.R.; Fagundes de Gouvea, P.; Malavazi, I.; Savoldi, M.; Gallmetzer, A.; Strauss, J.; Goldman, M.H.; Goldman, G.H.
    Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB) (2009), Fungal Genet. Biol., 46, 410-417.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form of L-methionine sulfoxide Aspergillus nidulans L-methionine + thioredoxin disulfide + H2O
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Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
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Aspergillus nidulans
MsrA
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Aspergillus nidulans

Cofactor

Cofactor Comment Organism Structure
thioredoxin
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Aspergillus nidulans

General Information

General Information Comment Organism
physiological function both single and double inactivation mutants are viable, but more sensitive to oxidative stress agents as hydrogen peroxide, paraquat, and ultraviolet light. These strains also accumulate more carbonylated proteins when exposed to hydrogen peroxide indicating that MsrA is an active player in the protection of the cellular proteins from oxidative stress damage Aspergillus nidulans