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Literature summary for 1.8.4.11 extracted from

  • Hanbauer, I.; Moskovitz, J.
    The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A (2006), Free Radic. Biol. Med., 40, 1391-1396.
    View publication on PubMed
Search for more literature for 1.8.4.11

Activating Compound

Activating Compound Comment Organism Structure
additional information H2O2 induces MsrA expression in a thioredoxin-dependent manner, msrA promoter and calcium phospholipid binding protein, CPBP, form a complex and enhance msrA expression, cytosolic thioredoxins 1 and 2 are involved in the regulation Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
gene msrA, msrA promoter and calcium phopsholipid binding protein, CPBP, form a complex and enhance msrA expression in absence of presence of H2O2, cytosolic thioredoxins 1 and 2 are involved in the regulation, overview Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information thioredoxin-deficient yeast strains show increased sensitivity to H2O2 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide-L-methionine-(S)-S-oxide + thioredoxin Saccharomyces cerevisiae MsrA regulation, overview peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Saccharomyces cerevisiae BY4743 MsrA regulation, overview peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 gene msrA
-
Saccharomyces cerevisiae BY4743
-
 gene msrA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dabsyl-L-methionine-(S)-S-oxide + DTT stereospecific reduction Saccharomyces cerevisiae dabsyl-L-methionine + DTT disulfide + H2O
-
 ?
dabsyl-L-methionine-(S)-S-oxide + DTT stereospecific reduction Saccharomyces cerevisiae BY4743 dabsyl-L-methionine + DTT disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Saccharomyces cerevisiae peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin MsrA regulation, overview Saccharomyces cerevisiae peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Saccharomyces cerevisiae BY4743 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin MsrA regulation, overview Saccharomyces cerevisiae BY4743 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
-
 Saccharomyces cerevisiae
MsrA
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
thioredoxin cytosolic thioredoxins 1 and 2 are involved in regulation of MsrA exression Saccharomyces cerevisiae