Cloned (Comment) | Organism |
---|---|
gene msrA, DNA and amino acid sequence determination and analysis, expression analysis, co-expression of A-type potassium channel ShC/B and MsrA in Xenopus laevis oocytes significantly accelerating the inactivation of the channel protein, functional expression of MsrA as GST-fusion protein in Escherichia coli strain BL21 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptide-L-methionine-(S)-S-oxide + thioredoxin | Homo sapiens | substrate is oxidized A-type potassium channel ShC/B whose activity strongly depends on the oxidative state of a methionine residue in the N-terminal part of the polypeptide | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | high MsrA expression level | Homo sapiens | - |
cerebellum | high MsrA expression level | Homo sapiens | - |
heart | ventricle, high MsrA expression level | Homo sapiens | - |
hippocampus | high MsrA expression level | Homo sapiens | - |
kidney | high MsrA expression level | Homo sapiens | - |
liver | high MsrA expression level, especially in fetal liver | Homo sapiens | - |
additional information | tissue expression analysis of MsrA, wide tissue distribution, no expression in leukemia and lymphoma cell lines | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Homo sapiens | N-acetyl-L-methionine + DTT disulfide + H2O | - |
? | |
N-acetyl-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | substrate is oxidized A-type potassium channel ShC/B whose activity strongly depends on the oxidative state of a methionine residue in the N-terminal part of the polypeptide | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Homo sapiens |
peptide methionine sulfoxide reductase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Homo sapiens | |
thioredoxin | - |
Homo sapiens |