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Literature summary for 1.8.4.11 extracted from
- Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus (2006), Biochem. Biophys. Res. Commun., 342, 145-152.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression analysis in suncellular fractions of melanocytes, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptide-L-methionine-(S)-S-oxide + thioredoxin | Homo sapiens | MsrA is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially by subcellular fractionation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | - |
Homo sapiens | - |
| melanocyte | epidermal | Homo sapiens | - |
| additional information | expression analysis of MsrA | Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
| peptide-L-methionine-(S)-S-oxide + thioredoxin | MsrA is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine sulfoxide reductase A | - |
Homo sapiens |
| MsrA | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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