Application | Comment | Organism |
---|---|---|
synthesis | enzyme can be useful in the development and action of anti-cancer and anti-inflammation drugs | Escherichia coli |
synthesis | enzyme can be useful in the development and action of anti-cancer and anti-inflammation drugs | Bos taurus |
Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Bos taurus |
gene msr or pilB, DNA sequence determination and analysis | Neisseria gonorrhoeae |
gene msrA, DNA and amino acid sequence determination and analysis, recombinant expression, functional overexpression of MsrB from gene msrB or yeaA | Escherichia coli |
gene msrA, DNA and amino acid sequence determination and analysis, recombinant expression, overexpression of MsrA leads to increased resistance to reactive oxygen species | Bos taurus |
overexpression of MsrA in T-lymphocytes and PC12 cells leads to increased resistance of the cells to reactive oxygen species and apoptotic death | Homo sapiens |
overexpression of MsrA leads to increased resistance to reactive oxygen species | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C52S | site-directed mutagenesis, inactive mutant, no protection of the cell against reactive oxygen species | Escherichia coli |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species | Saccharomyces cerevisiae |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and is 60% reduced binding to host lung cells | Streptococcus pneumoniae |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and shows decreased adherence to host cells | Haemophilus influenzae |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and shows decreased adherence to host cells | Neisseria gonorrhoeae |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and shows decreased adherence to host cells | Neisseria meningitidis |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and shows decreased adherence to host cells | Helicobacter pylori |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and shows decreased adherence to host cells | Streptococcus gordonii |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and shows decreased adherence to host cells, construction of a msrA/msrB double mutant for detection of additional enzyme form activities | Escherichia coli |
additional information | a knockout MsrA mutant strain is sensitive to reactive oxygen species and shows defective interaction with plant host cells | Dickeya chrysanthemi |
additional information | knockout mutants show shortened life span and have neurological lesions | Mus musculus |
additional information | transgenic flies overexpressing MsrA show increased extended life span, with extended time of physical and sexual activity, and increased resistance to paraquat | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | enzyme form Mem-R,S-Msr | Escherichia coli | 16020 | - |
microsome | calf, sulindac reducing activity | Bos taurus | - |
- |
additional information | subcellular sulindac reducing activity distribution in calf liver | Bos taurus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
x * 25000, MsrA | Drosophila melanogaster |
25000 | - |
x * 25000, MsrA | Haemophilus influenzae |
25000 | - |
x * 25000, MsrA | Mus musculus |
25000 | - |
x * 25000, MsrA | Escherichia coli |
25000 | - |
x * 25000, MsrA | Homo sapiens |
25000 | - |
x * 25000, MsrA | Saccharomyces cerevisiae |
25000 | - |
x * 25000, MsrA | Bos taurus |
25000 | - |
x * 25000, MsrA | Neisseria meningitidis |
25000 | - |
x * 25000, MsrA | Streptococcus pneumoniae |
25000 | - |
x * 25000, MsrA | Helicobacter pylori |
25000 | - |
x * 25000, MsrA | Dickeya chrysanthemi |
25000 | - |
x * 25000, MsrA | Streptococcus gordonii |
57000 | - |
x * 57000, MsrA/B | Neisseria gonorrhoeae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (R,S)-sulfoxide + thioredoxin | Haemophilus influenzae | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | Neisseria gonorrhoeae | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | Neisseria meningitidis | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | Streptococcus pneumoniae | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | Helicobacter pylori | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | Streptococcus gordonii | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | Escherichia coli | membrane-bound enzyme form Mem-R,S-Msr, enzyme form MsrA is specific for the S-form, MsrA enzyme form variants with specificities for either free or protein-bound methionine | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | Saccharomyces cerevisiae | MsrA is specific for the S-form, enzyme variants with specificities for either free or protein-bound methionine | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | Bos taurus | MsrA is specific for the S-form, enzyme variants with specificities for either free or protein-bound methionine | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | Drosophila melanogaster | MsrA is specific for the S-form, free and protein-bound methionine | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | Dickeya chrysanthemi | MsrA is specific for the S-form, free and protein-bound methionine | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | Mus musculus | MsrA is specific for the S-form, there exist enzyme variants with specificities for either free or protein-bound methionine | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | Homo sapiens | MsrA is specific for the S-form, there exist enzyme variants with specificities for either free or protein-bound methionine | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | Mus musculus | the enzyme protect cells against oxidative damage and plays a role in age-related diseases | ? | - |
? | |
additional information | Dickeya chrysanthemi | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | ? | - |
? | |
additional information | Escherichia coli | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions, the membrane-bound enzyme form Mem-R,S-Msr also utilizes the R-isomer of methionine sulfoxide as substrate | ? | - |
? | |
additional information | Homo sapiens | the enzyme protects cells against oxidative damage and plays a role in age-related and neurological diseases, like Parkinsons or Alzheimers disease | ? | - |
? | |
additional information | Drosophila melanogaster | the enzyme protects cells against oxidative damage and plays a role in age-related diseases | ? | - |
? | |
additional information | Saccharomyces cerevisiae | the enzyme protects cells against oxidative damage and plays a role in age-related diseases | ? | - |
? | |
additional information | Bos taurus | the enzyme protects cells against oxidative damage and plays a role in age-related diseases | ? | - |
? | |
additional information | Streptococcus pneumoniae | MsrA can protect cells against oxidative damage. A strain of Streptococcus pneumoniae that is defective in binding to lung cells has a mutation in the MsrA gene. The adherence of the MsrA mutant organism to lung cells is inhibited by about 60% | ? | - |
? | |
additional information | Escherichia coli | MsrA can protect cells against oxidative damage. Increased sensitivity to H2O2 of the Escherichia coli MsrA mutant | ? | - |
? | |
additional information | Dickeya chrysanthemi | MsrA can protect cells against oxidative damage. MsrA mutants of Erwinia chrysanthemi have a defective interaction with plant cells | ? | - |
? | |
additional information | Mus musculus | MsrA knockout mice have a shorter life span, are more sensitive to hyperbaric oxygen and had a neurological defect that resuls in abnormal walking | ? | - |
? | |
sulindac + thioredoxin | Bos taurus | activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr | sulindac sulfide + thioredoxin disulfide | activated drug which inhibits cyclooxygenase 1 and 2 and exhibiting anti-inflammatory activity | ? | |
sulindac + thioredoxin | Escherichia coli | activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr and MsrA | sulindac sulfide + thioredoxin disulfide | activated drug which inhibits cyclooxygenase 1 and 2 and exhibiting anti-inflammatory activity | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Dickeya chrysanthemi | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Escherichia coli | - |
- |
- |
Escherichia coli | - |
enzyme forms MsrA and Mem-R,S-Msr | - |
Haemophilus influenzae | - |
- |
- |
Haemophilus influenzae | - |
gene msr encodes an enzyme showing both MsrA, methionine S-oxide reductase (S-form oxidizing), and MsrB, methionine S-oxide reductase (R-form oxidizing), activity | - |
Helicobacter pylori | - |
- |
- |
Helicobacter pylori | - |
gene msr encodes an enzyme showing both MsrA, methionine S-oxide reductase (S-form oxidizing), and MsrB, methionine S-oxide reductase (R-form oxidizing), activity | - |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Neisseria gonorrhoeae | - |
- |
- |
Neisseria gonorrhoeae | - |
gene msr encodes an enzyme showing both MsrA, methionine S-oxide reductase (S-form oxidizing), and MsrB, methionine S-oxide reductase (R-form oxidizing), activity | - |
Neisseria meningitidis | - |
- |
- |
Neisseria meningitidis | - |
gene msr encodes an enzyme showing both MsrA and MsrB, methionine S-oxide reductase (R-form oxidizing), activity | - |
Saccharomyces cerevisiae | - |
- |
- |
Streptococcus gordonii | - |
- |
- |
Streptococcus gordonii | - |
gene msr encodes an enzyme showing both MsrA, methionine S-oxide reductase (S-form oxidizing), and MsrB, methionine S-oxide reductase (R-form oxidizing), activity | - |
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae | - |
gene msr encodes an enzyme showing both MsrA, methionine S-oxide reductase (S-form oxidizing), and MsrB, methionine S-oxide reductase (R-form oxidizing), activity | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involving the formation of a sulfenic acid intermediate, Cys52 is involved | Escherichia coli | |
L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involving the formation of a sulfenic acid intermediate, Cys72, Cys218 and Cys228 are involved | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | calf, sulindac reducing activity | Bos taurus | - |
kidney | calf, sulindac reducing activity | Bos taurus | - |
liver | calf, sulindac reducing activity | Bos taurus | - |
T-lymphocyte | overexpression of MsrA in human T-lymphocyte cells protects them against oxidative stress | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity in mutant strains | Escherichia coli |
additional information | - |
subcellular sulindac reducing activity in calf liver | Bos taurus |
0.00009 | - |
enzyme form Mem-R,S-Msr, substrate sulindac | Escherichia coli |
0.00019 | - |
enzyme form MsrA, substrate sulindac | Escherichia coli |
0.0018 | - |
wild-type strain, substrate L-methionine (S)-sulfoxide | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine (R,S)-sulfoxide + thioredoxin | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Haemophilus influenzae | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Neisseria gonorrhoeae | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Neisseria meningitidis | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Streptococcus pneumoniae | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Helicobacter pylori | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Streptococcus gordonii | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | enzyme MsrA/B shows both MsrA and MsrB activity, free and protein-bound methionine | Haemophilus influenzae | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | enzyme MsrA/B shows both MsrA and MsrB activity, free and protein-bound methionine | Neisseria gonorrhoeae | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | enzyme MsrA/B shows both MsrA and MsrB activity, free and protein-bound methionine | Neisseria meningitidis | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | enzyme MsrA/B shows both MsrA and MsrB activity, free and protein-bound methionine | Streptococcus pneumoniae | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | enzyme MsrA/B shows both MsrA and MsrB activity, free and protein-bound methionine | Helicobacter pylori | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (R,S)-sulfoxide + thioredoxin | enzyme MsrA/B shows both MsrA and MsrB activity, free and protein-bound methionine | Streptococcus gordonii | L-methionine + thioredoxin disulfide | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | membrane-bound enzyme form Mem-R,S-Msr, enzyme form MsrA is specific for the S-form, MsrA enzyme form variants with specificities for either free or protein-bound methionine | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | membrane-bound enzyme form Mem-R,S-Msr, enzyme form MsrA is specific for the S-form, there exist MsrA enzyme form variants with specificities for either free or protein-bound methionine | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, enzyme variants with specificities for either free or protein-bound methionine | Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, enzyme variants with specificities for either free or protein-bound methionine | Bos taurus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, free and protein-bound methionine | Drosophila melanogaster | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, free and protein-bound methionine | Dickeya chrysanthemi | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, there exist enzyme variants with specificities for either free or protein-bound methionine | Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, there exist enzyme variants with specificities for either free or protein-bound methionine | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine sulfoxide enkephalin + thioredoxin | membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | L-methionine enkephalin | - |
? | |
L-methionine-(S)-S-oxide + thioredoxin | - |
Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | the enzyme protect cells against oxidative damage and plays a role in age-related diseases | Mus musculus | ? | - |
? | |
additional information | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions | Dickeya chrysanthemi | ? | - |
? | |
additional information | the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions, the membrane-bound enzyme form Mem-R,S-Msr also utilizes the R-isomer of methionine sulfoxide as substrate | Escherichia coli | ? | - |
? | |
additional information | the enzyme protects cells against oxidative damage and plays a role in age-related and neurological diseases, like Parkinsons or Alzheimers disease | Homo sapiens | ? | - |
? | |
additional information | the enzyme protects cells against oxidative damage and plays a role in age-related diseases | Drosophila melanogaster | ? | - |
? | |
additional information | the enzyme protects cells against oxidative damage and plays a role in age-related diseases | Saccharomyces cerevisiae | ? | - |
? | |
additional information | the enzyme protects cells against oxidative damage and plays a role in age-related diseases | Bos taurus | ? | - |
? | |
additional information | enzyme reduces oxidized methionine residues of the alpha-1-proteinase inhibitor, calmodulin, and thrombomodulin, which become reversibly inactivated upon oxidation | Homo sapiens | ? | - |
? | |
additional information | enzyme reduces oxidized methionine residues of the shaker potassium channel, which becomes reversibly inactivated upon oxidation | Drosophila melanogaster | ? | - |
? | |
additional information | substrate specificity and activity of MsrB/PilB in comparison to MsrA, overview | Neisseria gonorrhoeae | ? | - |
? | |
additional information | substrate specificity of the different enzyme forms, overview, the membrane-bound enzyme form Mem-R,S-Msr also utilizes the R-isomer of methionine sulfoxide as substrate, enzyme reduces oxidized methionine residues of the ribosomal protein L12, which becomes reversibly inactivated and forms monomers instead of dimers upon oxidation | Escherichia coli | ? | - |
? | |
additional information | MsrA can protect cells against oxidative damage. A strain of Streptococcus pneumoniae that is defective in binding to lung cells has a mutation in the MsrA gene. The adherence of the MsrA mutant organism to lung cells is inhibited by about 60% | Streptococcus pneumoniae | ? | - |
? | |
additional information | MsrA can protect cells against oxidative damage. Increased sensitivity to H2O2 of the Escherichia coli MsrA mutant | Escherichia coli | ? | - |
? | |
additional information | MsrA can protect cells against oxidative damage. MsrA mutants of Erwinia chrysanthemi have a defective interaction with plant cells | Dickeya chrysanthemi | ? | - |
? | |
additional information | MsrA knockout mice have a shorter life span, are more sensitive to hyperbaric oxygen and had a neurological defect that resuls in abnormal walking | Mus musculus | ? | - |
? | |
N-acetyl-L-methionine (R,S)-sulfoxide + thioredoxin | enzyme MsrA/B shows both MsrA and MsrB activity, free and protein-bound methionine | Neisseria gonorrhoeae | N-acetyl-L-methionine + thioredoxin disulfide | - |
? | |
N-acetyl-L-methionine (R,S)-sulfoxide + thioredoxin | membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | N-acetyl-L-methionine + thioredoxin disulfide | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | - |
Escherichia coli | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
sulindac + thioredoxin | - |
Escherichia coli | sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
sulindac + thioredoxin | activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr | Bos taurus | sulindac sulfide + thioredoxin disulfide | activated drug which inhibits cyclooxygenase 1 and 2 and exhibiting anti-inflammatory activity | ? | |
sulindac + thioredoxin | activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr and MsrA | Escherichia coli | sulindac sulfide + thioredoxin disulfide | activated drug which inhibits cyclooxygenase 1 and 2 and exhibiting anti-inflammatory activity | ? | |
sulindac + thioredoxin | activity with membrane-bound enzyme form Mem-R,S-Msr and MsrA | Escherichia coli | sulindac sulfide + thioredoxin disulfide | - |
? | |
sulindac + thioredoxin | activity with membrane-bound enzyme form Mem-R,S-Msr and MsrA | Bos taurus | sulindac sulfide + thioredoxin disulfide | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 25000, MsrA | Drosophila melanogaster |
? | x * 25000, MsrA | Haemophilus influenzae |
? | x * 25000, MsrA | Mus musculus |
? | x * 25000, MsrA | Escherichia coli |
? | x * 25000, MsrA | Homo sapiens |
? | x * 25000, MsrA | Saccharomyces cerevisiae |
? | x * 25000, MsrA | Bos taurus |
? | x * 25000, MsrA | Neisseria meningitidis |
? | x * 25000, MsrA | Streptococcus pneumoniae |
? | x * 25000, MsrA | Helicobacter pylori |
? | x * 25000, MsrA | Dickeya chrysanthemi |
? | x * 25000, MsrA | Streptococcus gordonii |
? | x * 57000, MsrA/B | Neisseria gonorrhoeae |
More | the Cys residue within the conserved sequence motif GCFWG at the N-terminus is essential for catalytic activity | Escherichia coli |
More | the Cys residue within the conserved sequence motif GCFWG at the N-terminus is essential for catalytic activity | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase | - |
Drosophila melanogaster |
methionine sulfoxide reductase | - |
Haemophilus influenzae |
methionine sulfoxide reductase | - |
Mus musculus |
methionine sulfoxide reductase | - |
Escherichia coli |
methionine sulfoxide reductase | - |
Homo sapiens |
methionine sulfoxide reductase | - |
Saccharomyces cerevisiae |
methionine sulfoxide reductase | - |
Bos taurus |
methionine sulfoxide reductase | - |
Neisseria gonorrhoeae |
methionine sulfoxide reductase | - |
Neisseria meningitidis |
methionine sulfoxide reductase | - |
Streptococcus pneumoniae |
methionine sulfoxide reductase | - |
Helicobacter pylori |
methionine sulfoxide reductase | - |
Dickeya chrysanthemi |
methionine sulfoxide reductase | - |
Streptococcus gordonii |
MSR | - |
Haemophilus influenzae |
MSR | - |
Escherichia coli |
MSR | - |
Neisseria meningitidis |
MSR | - |
Streptococcus pneumoniae |
MSR | - |
Helicobacter pylori |
MSR | - |
Streptococcus gordonii |
MsrA | - |
Drosophila melanogaster |
MsrA | - |
Mus musculus |
MsrA | - |
Escherichia coli |
MsrA | - |
Homo sapiens |
MsrA | - |
Saccharomyces cerevisiae |
MsrA | - |
Bos taurus |
MsrA | - |
Streptococcus pneumoniae |
MsrA | - |
Dickeya chrysanthemi |
MsrA/B | - |
Neisseria gonorrhoeae |
MsrA/B | bifunctional enzyme: EC 1.8.4.11/EC 1.8.4.12 | Haemophilus influenzae |
MsrA/B | bifunctional enzyme: EC 1.8.4.11/EC 1.8.4.12 | Neisseria meningitidis |
MsrA/B | bifunctional enzyme: EC 1.8.4.11/EC 1.8.4.12 | Streptococcus pneumoniae |
MsrA/B | bifunctional enzyme: EC 1.8.4.11/EC 1.8.4.12 | Helicobacter pylori |
MsrA/B | bifunctional enzyme: EC 1.8.4.11/EC 1.8.4.12 | Streptococcus gordonii |
MsrA/B | enzyme contains activity of EC 1.8.4.11 and EC 1.8.4.12 | Neisseria gonorrhoeae |
PilB | - |
Neisseria gonorrhoeae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no activity with DTT as cofactor by membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | |
NADPH | membrane-bound enzyme form Mem-R,S-Msr | Escherichia coli | |
thioredoxin | - |
Drosophila melanogaster | |
thioredoxin | - |
Haemophilus influenzae | |
thioredoxin | - |
Mus musculus | |
thioredoxin | - |
Homo sapiens | |
thioredoxin | - |
Saccharomyces cerevisiae | |
thioredoxin | - |
Bos taurus | |
thioredoxin | - |
Neisseria gonorrhoeae | |
thioredoxin | - |
Neisseria meningitidis | |
thioredoxin | - |
Streptococcus pneumoniae | |
thioredoxin | - |
Helicobacter pylori | |
thioredoxin | - |
Dickeya chrysanthemi | |
thioredoxin | - |
Streptococcus gordonii | |
thioredoxin | preferred cofactor | Escherichia coli |