Application | Comment | Organism |
---|---|---|
medicine | TGR is a key target for antischistosomal drug development | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-DAP | 0.05 mM, complete inhibition | Schistosoma mansoni | |
auranofin | 0.05 mM, complete inhibition | Schistosoma mansoni | |
aurothioglucose | 0.05 mM, complete inhibition | Schistosoma mansoni | |
aurothiomalate | 0.05 mM, complete inhibition | Schistosoma mansoni | |
CDE16-2 | 0.05 mM, 98% inhibition | Schistosoma mansoni | |
CDE4 | 0.05 mM, 99% inhibition | Schistosoma mansoni | |
JD159 | 0.05 mM, complete inhibition | Schistosoma mansoni | |
LS826 | 0.05 mM, 95% inhibition | Schistosoma mansoni | |
naphthazarin | 0.05 mM, complete inhibition | Schistosoma mansoni | |
OPZ | 0.05 mM, 87% inhibition | Schistosoma mansoni | |
PAT | 0.05 mM, complete inhibition | Schistosoma mansoni | |
RMA35 | 0.05 mM, 98% inhibition | Schistosoma mansoni |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0137 | - |
NADPH | pH 7.4, 25°C | Schistosoma mansoni | |
0.0715 | - |
GSSG | pH 7.4, 25°C | Schistosoma mansoni | |
0.114 | - |
5,5'-dithiobis(2-nitrobenzoic acid) | pH 7.4, 25°C | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Schistosoma mansoni |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Schistosoma mansoni | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
GSSG + NADPH + H+ | - |
Schistosoma mansoni | GSH + NADP+ | - |
? | |
thioredoxin + NADP+ | - |
Schistosoma mansoni | thioredoxin disulfide + NADPH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TGR | - |
Schistosoma mansoni |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
16 | - |
5,5'-dithiobis(2-nitrobenzoic acid) | pH 7.4, 25°C | Schistosoma mansoni | |
20.1 | - |
NADPH | pH 7.4, 25°C | Schistosoma mansoni | |
21.7 | - |
GSSG | pH 7.4, 25°C | Schistosoma mansoni |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00001 | - |
auranofin | - |
Schistosoma mansoni |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000007 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | auranofin | |
0.000009 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | auranofin | |
0.000037 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | PAT | |
0.00005 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | aurothiomalate | |
0.000051 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | PAT | |
0.00007 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | aurothioglucose | |
0.00009 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | aurothiomalate | |
0.0005 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | 3-DAP | |
0.0005 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | JD159 | |
0.0005 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | CDE4 | |
0.001 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | CDE16-2 | |
0.001 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | JD159 | |
0.0025 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | naphthazarin | |
0.003 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | aurothioglucose | |
0.004 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | RMA35 | |
0.006 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | RMA35 | |
0.007 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | CDE4 | |
0.007 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | 3-DAP | |
0.008 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | LS826 | |
0.008 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | LS826 | |
0.01 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | naphthazarin | |
0.025 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | CDE16-2 | |
0.05 | - |
pH 7.4, 25°C, substrates: GSSG + NADPH | Schistosoma mansoni | OPZ | |
0.08 | - |
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | Schistosoma mansoni | OPZ |