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Literature summary for 1.8.1.9 extracted from
- Purification and characterization of Plasmodium berghei thioredoxin reductase (2011), Asian-australas. J. Anim. Sci., 5, 145-152.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-chloro-2,4-dinitrobenzene | uncompetitive inhibition | Plasmodium berghei |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.25 | - |
dithionitrobenzene | pH and temperature not specified in the publication | Plasmodium berghei | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Plasmodium berghei | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22000 | - |
x * 22000, SDS-PAGE | Plasmodium berghei |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | Plasmodium berghei | - |
thioredoxin + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium berghei | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation and Sephadex G-200 gel filtration | Plasmodium berghei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dithionitrobenzene + NADPH + H+ | - |
Plasmodium berghei | ? | - |
? | |
| thioredoxin disulfide + NADPH + H+ | - |
Plasmodium berghei | thioredoxin + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 22000, SDS-PAGE | Plasmodium berghei |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TrxR | - |
Plasmodium berghei |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Plasmodium berghei |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Plasmodium berghei | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.25 | 1.3 | 1-chloro-2,4-dinitrobenzene | pH and temperature not specified in the publication | Plasmodium berghei | |
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