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Literature summary for 1.8.1.9 extracted from

  • Lo, Y.C.; Ko, T.P.; Su, W.C.; Su, T.L.; Wang, A.H.
    Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1 (2009), J. Inorg. Biochem., 103, 1082-1092.
    View publication on PubMed
Search for more literature for 1.8.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with FAD, NADPH and/or (N-acetyl-4-aminothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride, sitting drop vapor diffusion method, using 5 mM MgSO4, 5% (w/v) PEG 3350, 50 mM MES pH 6.0 and 20% (w/v) 1,6-hexanediol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(4-ammoniothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride
-
 Homo sapiens
(4-ammoniothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate
-
 Homo sapiens
(4-hydroxylthiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride
-
 Homo sapiens
(4-hydroxylthiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) chloride
-
 Homo sapiens
(N-acetyl-4-aminothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride
-
 Homo sapiens
(N-acetyl-4-aminothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate
-
 Homo sapiens
cisplatin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16881
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+ affinity column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase 1
-
 Homo sapiens
TrxR1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005826
-
 in 50 mM Tris-HCl, pH 8.0, at 37°C Homo sapiens (4-hydroxylthiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) chloride
0.00006977
-
 in 50 mM Tris-HCl, pH 8.0, at 37°C Homo sapiens (4-hydroxylthiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride
0.00007002
-
 in 50 mM Tris-HCl, pH 8.0, at 37°C Homo sapiens (4-ammoniothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate
0.00007426
-
 in 50 mM Tris-HCl, pH 8.0, at 37°C Homo sapiens (N-acetyl-4-aminothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride
0.00007442
-
 in 50 mM Tris-HCl, pH 8.0, at 37°C Homo sapiens (4-ammoniothiophenolato)(2,2':6',2''-terpyridine)platinum(II) chloride
0.00007786
-
 in 50 mM Tris-HCl, pH 8.0, at 37°C Homo sapiens (N-acetyl-4-aminothiophenolato)(4'-toyl-2,2':6',2''-terpyridine)platinum(II) nitrate