Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoform Txnrd1 | Rattus norvegicus | 5829 | - |
mitochondrion | isoform Txnrd2 | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thioredoxin disulfide + NADPH + H+ | Rattus norvegicus | - |
thioredoxin + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thioredoxin disulfide + NADPH + H+ | - |
Rattus norvegicus | thioredoxin + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase 1 | - |
Rattus norvegicus |
Txnrd1 | isoform | Rattus norvegicus |
Txnrd2 | isoform | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | Txnrd1 knock-out cells cannot be rescued from glutathione depletion-induced cell death either by antioxidants, xCT overexpression, or co-culturing with xCT-overexpressing cells that condition the medium with Cys | Rattus norvegicus |
physiological function | glutathione deficiency can be rescued by forced expression of xCT (the substrate-specific subunit of the cystine/glutamate antiporter), which additionally requires the presence of functional isoform Txnrd1, but not isoform Txnrd2 | Rattus norvegicus |