Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.9 extracted from

  • Prast-Nielsen, S.; Cebula, M.; Pader, I.; Arner, E.S.
    Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin (2010), Free Radic. Biol. Med., 49, 1765-1778.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
auranofin about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 80% residual activity at 400 nM for juglone reduction Homo sapiens
auranofin about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 80% residual activity at 400 nM for juglone reduction Rattus norvegicus
cisplatin i.e. cis-diamminedichloroplatinum(II), about 3% residual activity at 400 nM in the presence of NADPH, about 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Homo sapiens
cisplatin i.e. cis-diamminedichloroplatinum(II), about 3% residual activity at 400 nM in the presence of NADPH, about 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Rattus norvegicus
gold potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Homo sapiens
gold potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Rattus norvegicus
K2PdCl4 strong and irreversible inhibition, about 30% residual activity at 400 nM in the presence of NADPH, less than 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Homo sapiens
K2PdCl4 strong and irreversible inhibition, about 30% residual activity at 400 nM in the presence of NADPH, less than 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction Rattus norvegicus
K2PdCl6 irreversible inhibition Homo sapiens
K2PdCl6 irreversible inhibition Rattus norvegicus
K2PtCl4 irreversible inhibition, about 5% residual activity at 400 nM in the presence of NADPH, complete inhibition of 5,5'-dithiobis(2-nitrobenzoic acid) reduction at 400 nM, about 90% residual activity at 400 nM for juglone reduction Homo sapiens
K2PtCl4 irreversible inhibition, about 5% residual activity at 400 nM in the presence of NADPH, complete inhibition of 5,5'-dithiobis(2-nitrobenzoic acid) reduction at 400 nM, about 90% residual activity at 400 nM for juglone reduction Rattus norvegicus
K2PtCl6 irreversible inhibition Homo sapiens
K2PtCl6 irreversible inhibition Rattus norvegicus
KAuCl4 irreversible inhibition, about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 70% residual activity at 400 nM for juglone reduction Homo sapiens
KAuCl4 irreversible inhibition, about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 70% residual activity at 400 nM for juglone reduction Rattus norvegicus
palladium potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Homo sapiens
palladium potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Rattus norvegicus
platinum the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Homo sapiens
platinum the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
SDS-PAGE Homo sapiens
65000
-
SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
NCI-H23 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
?
juglone + NADPH + H+
-
Homo sapiens ?
-
?
juglone + NADPH + H+
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Homo sapiens
thioredoxin reductase
-
Rattus norvegicus
TrxR1
-
Homo sapiens
TrxR1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
FAD
-
Rattus norvegicus
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus