Inhibitors | Comment | Organism | Structure |
---|---|---|---|
auranofin | about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 80% residual activity at 400 nM for juglone reduction | Homo sapiens | |
auranofin | about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 80% residual activity at 400 nM for juglone reduction | Rattus norvegicus | |
cisplatin | i.e. cis-diamminedichloroplatinum(II), about 3% residual activity at 400 nM in the presence of NADPH, about 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction | Homo sapiens | |
cisplatin | i.e. cis-diamminedichloroplatinum(II), about 3% residual activity at 400 nM in the presence of NADPH, about 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction | Rattus norvegicus | |
gold | potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA | Homo sapiens | |
gold | potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA | Rattus norvegicus | |
K2PdCl4 | strong and irreversible inhibition, about 30% residual activity at 400 nM in the presence of NADPH, less than 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction | Homo sapiens | |
K2PdCl4 | strong and irreversible inhibition, about 30% residual activity at 400 nM in the presence of NADPH, less than 10% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 90% residual activity at 400 nM for juglone reduction | Rattus norvegicus | |
K2PdCl6 | irreversible inhibition | Homo sapiens | |
K2PdCl6 | irreversible inhibition | Rattus norvegicus | |
K2PtCl4 | irreversible inhibition, about 5% residual activity at 400 nM in the presence of NADPH, complete inhibition of 5,5'-dithiobis(2-nitrobenzoic acid) reduction at 400 nM, about 90% residual activity at 400 nM for juglone reduction | Homo sapiens | |
K2PtCl4 | irreversible inhibition, about 5% residual activity at 400 nM in the presence of NADPH, complete inhibition of 5,5'-dithiobis(2-nitrobenzoic acid) reduction at 400 nM, about 90% residual activity at 400 nM for juglone reduction | Rattus norvegicus | |
K2PtCl6 | irreversible inhibition | Homo sapiens | |
K2PtCl6 | irreversible inhibition | Rattus norvegicus | |
KAuCl4 | irreversible inhibition, about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 70% residual activity at 400 nM for juglone reduction | Homo sapiens | |
KAuCl4 | irreversible inhibition, about 10% residual activity at 400 nM in the presence of NADPH, less than 5% residual activity at 400 nM for 5,5'-dithiobis(2-nitrobenzoic acid) reduction, about 70% residual activity at 400 nM for juglone reduction | Rattus norvegicus | |
palladium | potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA | Homo sapiens | |
palladium | potent inhibitor, the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA | Rattus norvegicus | |
platinum | the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA | Homo sapiens | |
platinum | the inhibition of TrxR1 by the metal compound is not markedly influenced by the presence of EDTA | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
SDS-PAGE | Homo sapiens |
65000 | - |
SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
NCI-H23 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Rattus norvegicus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
juglone + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
juglone + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Homo sapiens |
thioredoxin reductase | - |
Rattus norvegicus |
TrxR1 | - |
Homo sapiens |
TrxR1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Rattus norvegicus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |