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Literature summary for 1.8.1.9 extracted from

  • Carvalho, C.M.; Lu, J.; Zhang, X.; Arner, E.S.; Holmgren, A.
    Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning (2011), FASEB J., 25, 370-381.
    View publication on PubMed
Search for more literature for 1.8.1.9

Inhibitors

Inhibitors Comment Organism Structure
Hg2+ in the presence of NADPH, a ratio of 2 HgCl2 molecules to 1 TrxR dimer leads to a virtually inactive enzyme. On treatment with 0.005 mM selenite and NADPH, TrxR inactivated by HgCl2 displays almost full recovery of activity Homo sapiens
Hg2+ in the presence of NADPH, a ratio of 2 HgCl2 molecules to 1 TrxR dimer leads to a virtually inactive enzyme. On treatment with 0.005 mM selenite and NADPH, TrxR inactivated by HgCl2 displays almost full recovery of activity Rattus norvegicus
methylmercury in the case of methylmercury, a ratio of 16 molecules per dimer leads to a virtually inactive enzyme Homo sapiens
methylmercury in the case of methylmercury, a ratio of 16 molecules per dimer leads to a virtually inactive enzyme Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 2 * 58000, SDS-PAGE Homo sapiens
58000
-
 2 * 58000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin + NADPH + H+
-
 Homo sapiens ? + NADP+
-
 ?
insulin + NADPH + H+
-
 Rattus norvegicus ? + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Homo sapiens thioredoxin + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Rattus norvegicus thioredoxin + NADP+
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 58000, SDS-PAGE Homo sapiens
homodimer 2 * 58000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
 Homo sapiens
thioredoxin reductase
-
 Rattus norvegicus
TrxR
-
 Homo sapiens
TrxR
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
FAD
-
 Rattus norvegicus
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the thioredoxin system, comprising thioredoxin, thioredoxin reductase, and NADPH, is critical for cellular stress response, protein repair, and protection against oxidative damage Homo sapiens
physiological function the thioredoxin system, comprising thioredoxin, thioredoxin reductase, and NADPH, is critical for cellular stress response, protein repair, and protection against oxidative damage Rattus norvegicus