Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.9 extracted from

  • Sorrentino, F.; Karioti, A.; Gratteri, P.; Rigobello, M.P.; Scutari, G.; Messori, L.; Bindoli, A.; Chioccioli, M.; Gabbiani, C.; Bergonzi, M.C.; Bilia, A.R.
    Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones (2011), Bioorg. Med. Chem., 19, 631-641.
    View publication on PubMed
Search for more literature for 1.8.1.9

Inhibitors

Inhibitors Comment Organism Structure
1,4-dihydroxyanthroquinone
-
 Rattus norvegicus
1,8-dihydroxyanthroquinone
-
 Rattus norvegicus
aloe emodin
-
 Rattus norvegicus
aloin A
-
 Rattus norvegicus
anthrone
-
 Rattus norvegicus
chrysophanol
-
 Rattus norvegicus
frangulin A
-
 Rattus norvegicus
hypericin
-
 Rattus norvegicus
physcion
-
 Rattus norvegicus
pseudohypericin strong inhibitor of isoform TrxR1 Rattus norvegicus
Rhein
-
 Rattus norvegicus
sennoside A
-
 Rattus norvegicus
sennoside B
-
 Rattus norvegicus
skyrin glucoside
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoform TrxR1 Rattus norvegicus 5829
-
mitochondrion isoform TrxR2 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thioredoxin disulfide + NADPH + H+ Rattus norvegicus
-
 thioredoxin + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O89049 isoform TrxR1
-
Rattus norvegicus Q9Z0J5 isoform TrxR2
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Rattus norvegicus thioredoxin + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
 Rattus norvegicus
TrxR1 isoform Rattus norvegicus
TrxR2 isoform Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rattus norvegicus
NADPH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0046
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus pseudohypericin
0.0079
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus pseudohypericin
0.049
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus hypericin
0.084
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus Rhein
0.123
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus Rhein
0.132
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus physcion
0.18
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloe emodin
0.181
-
 isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus chrysophanol
0.185
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus physcion
0.194
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus chrysophanol
0.198
-
 isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus hypericin
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus anthrone
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus 1,4-dihydroxyanthroquinone
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus 1,8-dihydroxyanthroquinone
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloin A
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside A
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside B
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus frangulin A
0.2
-
 IC50 above 0.2 mM, isoform TrxR1, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus skyrin glucoside
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus anthrone
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus 1,4-dihydroxyanthroquinone
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloe emodin
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus aloin A
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside A
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus sennoside B
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus frangulin A
0.2
-
 IC50 above 0.2 mM, isoform TrxR2, at 25°C in 0.2 M Na, K-phosphate buffer (pH 7.4) Rattus norvegicus skyrin glucoside