Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae W303-1A | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thioredoxin disulfide + NADPH + H+ | - |
Saccharomyces cerevisiae | thioredoxin + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Saccharomyces cerevisiae W303-1A | thioredoxin + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase 1 | - |
Saccharomyces cerevisiae |
Trr1 | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Saccharomyces cerevisiae | |
NADPH | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. Decreased reporter gene activity in thioredoxin reductase null cells is due to reduced p53 specific activity rather than reduced p53 protein levels | Saccharomyces cerevisiae |