Protein Variants | Comment | Organism |
---|---|---|
U498C | specific activity of 50% of wild-type enzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
myricetin | 0.05 mM, strong inhibitory effect, IC50: 0.62 mM | Rattus norvegicus | |
quercetin | 0.05 mM, strong inhibitory effect, IC50: 0.97 mM | Rattus norvegicus | |
reactive oxygen species | 0.1 mM, ROS generated by xanthine/xanthine oxidase enhance the inhibitory effect of flavonoids | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
57000 | - |
2 * 57000, SDS-PAGE | Rattus norvegicus |
115000 | - |
SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | - |
Rattus norvegicus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
thioredoxin + NADP+ | - |
Rattus norvegicus | thioredoxin disulfide + NADPH | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 57000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Rattus norvegicus |
TrxR | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.62 | - |
0.05 mM, strong inhibitory effect, IC50: 0.62 mM | Rattus norvegicus | myricetin | |
0.97 | - |
0.05 mM, strong inhibitory effect, IC50: 0.97 mM | Rattus norvegicus | quercetin |