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Literature summary for 1.8.1.9 extracted from

  • Lu, J.; Papp, L.V.; Fang, J.; Rodriguez-Nieto, S.; Zhivotovsky, B.; Holmgren, A.
    Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity (2006), Cancer Res., 66, 4410-4418.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
U498C specific activity of 50% of wild-type enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
myricetin 0.05 mM, strong inhibitory effect, IC50: 0.62 mM Rattus norvegicus
quercetin 0.05 mM, strong inhibitory effect, IC50: 0.97 mM Rattus norvegicus
reactive oxygen species 0.1 mM, ROS generated by xanthine/xanthine oxidase enhance the inhibitory effect of flavonoids Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
2 * 57000, SDS-PAGE Rattus norvegicus
115000
-
SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
-
Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
?
thioredoxin + NADP+
-
Rattus norvegicus thioredoxin disulfide + NADPH
-
?

Subunits

Subunits Comment Organism
dimer 2 * 57000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Rattus norvegicus
TrxR
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.62
-
0.05 mM, strong inhibitory effect, IC50: 0.62 mM Rattus norvegicus myricetin
0.97
-
0.05 mM, strong inhibitory effect, IC50: 0.97 mM Rattus norvegicus quercetin