Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cysteine | C-terminal redox active disulfide | Drosophila melanogaster | |
cysteine | C-terminal redox active disulfide | Homo sapiens | |
cysteine | C-terminal redox active disulfide | Plasmodium falciparum | |
cysteine | part of the active site | Drosophila melanogaster | |
cysteine | part of the active site | Homo sapiens | |
cysteine | part of the active site | Plasmodium falciparum |
Protein Variants | Comment | Organism |
---|---|---|
C73S | recombinant, His-tagged | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
auranofin | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
methylseleninate | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
recombinant | - |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Plasmodium falciparum | - |
recombinant | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Drosophila melanogaster | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Mus musculus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Plasmodium falciparum | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | coupled assay | Drosophila melanogaster | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | coupled assay | Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | coupled assay | Plasmodium falciparum | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
GSSG + NADPH | in presence of methylselenol | Homo sapiens | GSH + NADP+ | - |
r | |
methylseleninate + H2O2 | - |
Drosophila melanogaster | ? | - |
? | |
methylseleninate + H2O2 | - |
Mus musculus | ? | - |
? | |
methylseleninate + H2O2 | - |
Plasmodium falciparum | ? | - |
? | |
methylseleninate + H2O2 | in presence of methylseleninate | Homo sapiens | ? | - |
? | |
methylseleninate + NADPH | also utilizes glutathione instead of NADPH | Homo sapiens | CH3SeH + NADP+ | - |
ir | |
seleninate + NADPH | - |
Homo sapiens | ? | - |
? | |
thioredoxin + NADP+ | - |
Mus musculus | thioredoxin disulfide + NADPH | - |
r | |
thioredoxin + NADP+ | coupled assay with DTNB | Drosophila melanogaster | thioredoxin disulfide + NADPH | - |
r | |
thioredoxin + NADP+ | coupled assay with DTNB | Homo sapiens | thioredoxin disulfide + NADPH | - |
r | |
thioredoxin + NADP+ | coupled assay with DTNB | Plasmodium falciparum | thioredoxin disulfide + NADPH | - |
r | |
thioredoxin + tert-butyl-hydroperoxide | in presence of methylseleninate, coupled assay | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TrxR | - |
Drosophila melanogaster |
TrxR | - |
Mus musculus |
TrxR | - |
Homo sapiens |
TrxR | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
12 | - |
methylseleninate | recombinant protein | Drosophila melanogaster | |
14 | - |
methylseleninate | - |
Mus musculus | |
23 | - |
methylseleninate | - |
Homo sapiens | |
31 | - |
methylseleninate | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Drosophila melanogaster | |
FAD | - |
Mus musculus | |
FAD | - |
Homo sapiens | |
FAD | - |
Plasmodium falciparum | |
NADPH | - |
Drosophila melanogaster | |
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Plasmodium falciparum |