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Literature summary for 1.8.1.7 extracted from

  • Parrilha, G.L.; Ferraz, K.S.; Lessa, J.A.; de Oliveira, K.N.; Rodrigues, B.L.; Ramos, J.P.; Souza-Fagundes, E.M.; Ott, I.; Beraldo, H.
    Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase (2014), Eur. J. Med. Chem., 84, 537-544 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
chloro[N(4)-ortho-chlorophenyl-2-acetylpyridinethiosemicarbazonato]gold(III)dichloroaurate(I) in addition, the complex is highly cytotoxic to MCF-7 and HT29 cells Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00122
-
pH 7.0, 37°C Rattus norvegicus chloro[N(4)-ortho-chlorophenyl-2-acetylpyridinethiosemicarbazonato]gold(III)dichloroaurate(I)