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Literature summary for 1.8.1.7 extracted from

  • Ku, M.; Baek, Y.U.; Kwak, M.K.; Kang, S.O.
    Candida albicans glutathione reductase downregulates Efg1-mediated cyclic AMP/protein kinase A pathway and leads to defective hyphal growth and virulence upon decreased cellular methylglyoxal content accompanied by activating alcohol dehydrogenase and glycolytic enzymes (2017), Biochim. Biophys. Acta, 1861, 772-788 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Candida albicans Q59NQ5
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function a GLR1-deficient strain is not viable. During filamentation, nongrowing hyphal GLR1-overexpressing cells exhibit resistance against oxidants and cellular methylglyoxal is significantly decreased, which concomitantly increases expression of genes encoding energy-generating enzymes, including fructose-1,6-bisphosphate aldolase, glyceraldehyde-3-phosphate dehydrogenase, and alcohol dehydrogenase (ADH1), with remarkable repression of Efg1-signaling cascades Candida albicans