Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acylfulvene | reversible inhibition, less than 10% residual activity at 1.25 mM, inhibition by 1.0 or 1.25 mM acylfulvene is reduced by 30% in the presence of NDPH | Saccharomyces cerevisiae | |
carmustine | i.e. 1,3-bis(2-chloroethyl)-1-nitroso-urea, irreversible inhibitor, complete inhibition at 0.625 mM | Saccharomyces cerevisiae | |
hydroxymethylacylfulvene | irreversible inhibition, less than 10% residual activity at 1.25 mM, inhibition by 0.625 or 1.25 mM hydroxymethylacylfulvene is reduced by 45% in the presence of NDPH | Saccharomyces cerevisiae | |
illudin S | - |
Saccharomyces cerevisiae | |
additional information | up to 2 mM, illudin S does not inhibit glutathione reductase activity | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Saccharomyces cerevisiae | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EC 1.6.4.2 | formerly | Saccharomyces cerevisiae |
glutathione reductase | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Saccharomyces cerevisiae | |
NADPH | - |
Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
hydroxymethylacylfulvene | at 25°C, pH not specified in the publication | Saccharomyces cerevisiae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.071 | - |
at 25°C, pH not specified in the publication | Saccharomyces cerevisiae | carmustine | |
0.216 | - |
at 25°C, pH not specified in the publication | Saccharomyces cerevisiae | hydroxymethylacylfulvene | |
0.871 | - |
at 25°C, pH not specified in the publication | Saccharomyces cerevisiae | acylfulvene |