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Literature summary for 1.8.1.7 extracted from

  • Tandogan, B.; Ulusu, N.N.
    Inhibition of purified bovine liver glutathione reductase with some metal ions (2010), J. Enzyme Inhib. Med. Chem., 25, 68-73.
    View publication on PubMed
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ non-competitive inhibition with respect to both NADPH and GSSG Bos taurus
additional information glutathione reductase is not influenced by Al3+, Ba2+, Mn2+, and Li+ at 0.01-0.1 mM, and by Ca2+ and Mo6+ at 0.005-0.125 mM Bos taurus
Ni2+ non-competitive inhibition with respect to GSSG and uncompetitive inhibition with respect to NADPH Bos taurus
Zn2+ non-competitive inhibition with respect to both NADPH and GSSG Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSSG + NADPH + H+
-
 Bos taurus glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
EC 1.6.4.2 formerly Bos taurus
glutathione reductase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Bos taurus
NADPH
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.113
-
 Cd2+ with NADPH as the varied substrate, pH 7.4, 37°C Bos taurus
0.221
-
 Cd2+ with GSSG as the varied substrate, pH 7.4, 37°C Bos taurus
0.313
-
 Ni2+ with GSSG as the varied substrate, pH 7.4, 37°C Bos taurus
0.32
-
 Zn2+ with GSSG as the varied substrate, pH 7.4, 37°C Bos taurus
0.761
-
 Zn2+ with NADPH as the varied substrate, pH 7.4, 37°C Bos taurus
0.932
-
 Ni2+ with NADPH as the varied substrate, pH 7.4, 37°C Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.08
-
 pH 7.4, 37°C Bos taurus Cd2+
0.8
-
 pH 7.4, 37°C Bos taurus Ni2+
1
-
 pH 7.4, 37°C Bos taurus Zn2+