Literature summary for 1.8.1.7 extracted from

Franco, J.L.; Posser, T.; Mattos, J.J.; Sanchez-Chardi, A.; Trevisan, R.; Oliveira, C.S.; Carvalho, P.S.; Leal, R.B.; Marques, M.R.; Bainy, A.C.; Dafre, A.L.
Biochemical alterations in juvenile carp (Cyprinus carpio) exposed to zinc: glutathione reductase as a target (2008), Mar. Environ. Res., 66, 88-89.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Zn2+	-	Cyprinus carpio

Organism

Organism	UniProt	Comment	Textmining
Cyprinus carpio	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Cyprinus carpio	-
gill	-	Cyprinus carpio	-
liver	-	Cyprinus carpio	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione disulfide + NADPH + H+	-	Cyprinus carpio	glutathione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
glutathione reductase	-	Cyprinus carpio

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Cyprinus carpio

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.007	-	-	Cyprinus carpio	Zn2+

Expression

Organism	Comment	Expression
Cyprinus carpio	zinc exposure (0.01, 0.03, and 0.1 mM Zn2+ for a period of 48 h) causes a concentration-dependent reduction in glutathione reductase activity in gills, liver and brain	down

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Release 2023.1 (January 2023)