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Literature summary for 1.8.1.7 extracted from

  • Senturk, M.; Kufrevioglu, O.I.; Ciftci, M.
    Effects of some antibiotics on human erythrocyte glutathione reductase: an in vitro study (2008), J. Enzyme Inhib. Med. Chem., 23, 144-148.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
amikacin
-
Homo sapiens
amoxicillin
-
Homo sapiens
clindamycin
-
Homo sapiens
Lincomycin
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ceftazidime competitive inhibition Homo sapiens
ceftriaxone competitive inhibition Homo sapiens
cefuroxime competitive inhibition Homo sapiens
chloramphenicol competitive inhibition Homo sapiens
Imipenem competitive inhibition Homo sapiens
ornidazole competitive inhibition Homo sapiens
rifamycin competitive inhibition Homo sapiens
sulfanylacetamide competitive inhibition Homo sapiens
Vancomycin noncompetitive inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B column chromatography and Sephadex G-200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01
-
hemolysate, at 25°C, pH 8.0 Homo sapiens
28
-
after 2800fold purification, at 25°C, pH 8.0 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
?

Synonyms

Synonyms Comment Organism
EC 1.6.4.2 formerly Homo sapiens
glutathione reductase
-
Homo sapiens
NADPH:oxidized glutathione oxidoreductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.06
-
Imipenem at 25°C, pH 8.0 Homo sapiens
0.085
-
sulfanylacetamide at 25°C, pH 8.0 Homo sapiens
0.275
-
rifamycin at 25°C, pH 8.0 Homo sapiens
3.59
-
ceftazidime at 25°C, pH 8.0 Homo sapiens
3.71
-
ceftriaxone at 25°C, pH 8.0 Homo sapiens
3.85
-
chloramphenicol at 25°C, pH 8.0 Homo sapiens
15.11
-
Vancomycin at 25°C, pH 8.0 Homo sapiens
23.5
-
cefuroxime at 25°C, pH 8.0 Homo sapiens
28.49
-
ornidazole at 25°C, pH 8.0 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03
-
at 25°C, pH 8.0 Homo sapiens Imipenem
0.146
-
at 25°C, pH 8.0 Homo sapiens rifamycin
0.59
-
at 25°C, pH 8.0 Homo sapiens sulfanylacetamide
2.36
-
at 25°C, pH 8.0 Homo sapiens chloramphenicol
2.476
-
at 25°C, pH 8.0 Homo sapiens ceftazidime
2.88
-
at 25°C, pH 8.0 Homo sapiens ceftriaxone
4.83
-
at 25°C, pH 8.0 Homo sapiens Vancomycin
15.43
-
at 25°C, pH 8.0 Homo sapiens cefuroxime
19.63
-
at 25°C, pH 8.0 Homo sapiens ornidazole