Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | addition of exogenous Fe2+ (but not Fe3+) potentiates NADPH-induced inactivation of glutathione reductase, after a 2 min incubation period, 0.05 mM Fe2+ plus 0.3 mM NADPH induce 57% loss of enzyme activity | Saccharomyces cerevisiae | |
NADPH | 58% inhibition at 0.3 mM after 60 min incubation, exogenously added antioxidants including ethanol, dimethylsulfoxide and 2-deoxyribose do not protect glutathione reductase against NADPH-induced inactivation, whilst addition of exogenous Fe2+ (but not Fe3+) potentiates the inactivation, removal of oxygen from the medium leads to increased inhibition of glutathione reductase, whereas pre-incubation of the Fe2+-containing medium for 30 min under normoxic conditions prior to the addition of GR abolishes the enzyme inactivation by NADPH | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Saccharomyces cerevisiae | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione reductase | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Saccharomyces cerevisiae | |
NADPH | - |
Saccharomyces cerevisiae |