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Literature summary for 1.8.1.7 extracted from

  • Sentuerk, M.; Guelcin, I.; Ciftci, M.; Kuefrevioglu, O.I.
    Dantrolene inhibits human erythrocyte glutathione reductase (2008), Biol. Pharm. Bull., 31, 2036-2039.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dantrolene non-competitive inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate precipitation, 2 ',5'-ADP Sepharose-4B affinity column chromatography and Sephadex G-200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.009
-
hemolysate, at 25°C, pH 8.0 Homo sapiens
23
-
2555fold purified enzyme, at 25°C, pH 8.0 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
r

Synonyms

Synonyms Comment Organism
glutathione reductase
-
Homo sapiens
glutathione: NADP+ oxidoreductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1116
-
dantrolene at 25°C, pH 8.0 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0523
-
at 25°C, pH 8.0 Homo sapiens dantrolene