Literature summary for 1.8.1.7 extracted from

Witte, A.B.; Anestal, K.; Jerremalm, E.; Ehrsson, H.; Arner, E.S.
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds (2005), Free Radic. Biol. Med., 39, 696-703.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cisplatin	0.01-0.2 mM	Saccharomyces cerevisiae
monohydrated complex of cisplatin	0.01-0.2 mM	Saccharomyces cerevisiae
additional information	no inhibition by chlorambucil, melphalan, busulfan and carboplatin	Saccharomyces cerevisiae
oxaliplatin	0.01-0.2 mM	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione disulfide + NADPH + H+	-	Saccharomyces cerevisiae	glutathione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
glutathione reductase	-	Saccharomyces cerevisiae
GR	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)