Inhibitors | Comment | Organism | Structure |
---|---|---|---|
auranofin | complete inhibition of both enzyme reductase activities at 10 nM | Taenia crassiceps |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics, hysteretic behaviour | Taenia crassiceps | |
0.003 | - |
NADPH | pH 7.8, 25°C | Taenia crassiceps | |
0.015 | - |
glutathione disulfide | pH 7.8, 25°C | Taenia crassiceps |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Taenia crassiceps | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
2 * 65000, SDS-PAGE | Taenia crassiceps |
136000 | - |
gel filtration | Taenia crassiceps |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH | Taenia crassiceps | - |
glutathione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taenia crassiceps | - |
parasite isolated from mice, enzyme is a multifunctional thioredoxin-glutathione reductase TGR | - |
Purification (Comment) | Organism |
---|---|
647fold to homogeneity from metacystodes by ammonium sulfate fractionation, ion exchange chromatography, affinity chromatography, and gel filtration | Taenia crassiceps |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | the multifunctional enzyme possesses both thioredoxin reductase activity, EC 1.8.1.9, glutathione reductase activity, EC 1.8.1.7, and glutaredoxin activity | Taenia crassiceps |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
metacestode | i.e. cysticeri, recovered from peritoneal cavity of 6-8 months before inoculated female Balb/c mice | Taenia crassiceps | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
4.9 | - |
purified enzyme, substrate glutathione disulfide | Taenia crassiceps |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH | - |
Taenia crassiceps | glutathione + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 65000, SDS-PAGE | Taenia crassiceps |
Synonyms | Comment | Organism |
---|---|---|
multifunctional thioredoxin-glutathione reductase | - |
Taenia crassiceps |
TGR | - |
Taenia crassiceps |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Taenia crassiceps |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Taenia crassiceps |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | 1.2 mol per mol of enzyme subunit bound | Taenia crassiceps | |
NADPH | - |
Taenia crassiceps |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Taenia crassiceps | isoelectric focusing | - |
5.2 |