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Literature summary for 1.8.1.7 extracted from
- Purification and properties of a disulfide reductase obtained from Achromobacter starkeyi (1968), J. Biol. Chem., 243, 4083-4088.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arsenite | - |
Achromobacter starkeyi |  |
| Ca2+ | - |
Achromobacter starkeyi | |
| Cu2+ | - |
Achromobacter starkeyi | |
| Hg2+ | - |
Achromobacter starkeyi | |
| iodoacetate | - |
Achromobacter starkeyi | |
| Mg2+ | - |
Achromobacter starkeyi | |
| Mn2+ | - |
Achromobacter starkeyi | |
| N-ethylmaleimide | slight | Achromobacter starkeyi | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSSG + NADPH | Achromobacter starkeyi | specific for GSSG | glutathione + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Achromobacter starkeyi | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Achromobacter starkeyi |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.18 | - |
- |
Achromobacter starkeyi |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 2-3 months | Achromobacter starkeyi |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSSG + NADPH | 5,5'-dithiobis(2-nitrobenzoic acid) | Achromobacter starkeyi | glutathione + NADP+ | - |
? | |
| GSSG + NADPH | specific for GSSG | Achromobacter starkeyi | glutathione + NADP+ | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
- |
Achromobacter starkeyi |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 15 | 40 | 15°C: about 25% of activity maximum, 40°C: about 50% of activity maximum | Achromobacter starkeyi |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Achromobacter starkeyi |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | enzyme can utilize both NADH and NADPH, more active with NADPH | Achromobacter starkeyi | |
| NADPH | can utilize both NADPH and NADH, more active with NADPH | Achromobacter starkeyi | |
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Release 2023.1 (January 2023)
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