Literature summary for 1.8.1.4 extracted from

Luis, P.B.; Ruiter, J.P.; Aires, C.C.; Soveral, G.; de Almeida, I.T.; Duran, M.; Wanders, R.J.; Silva, M.F.
Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation (2007), Biochim. Biophys. Acta, 1767, 1126-1133.

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Application

Application	Comment	Organism
degradation	decreased activity of DLDH induced by valproic acid metabolites may, at least in part, account for the impaired rate of oxygen consumption and ATP synthesis in mitochondria if 2-oxoglutarate or glutamate are used as respiratory substrates, thus limiting the flux of these substrates through the citric acid cycle	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
valproyl-CoA	competitive inhibitor, 0.5-1.0 mM inhibit DLDH activity	Rattus norvegicus
valproyl-dephosphoCoA	uncompetitive inhibitor, 0.5-1.0 mM inhibit DLDH activity	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydrolipoamide + NAD+	-	Rattus norvegicus	lipoamide + NADH	-	?

Synonyms

Synonyms	Comment	Organism
dihydrolipoamide dehydrogenase	-	Rattus norvegicus
DLDH	-	Rattus norvegicus
E3	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.43	-	valproyl-CoA	-	Rattus norvegicus
1.6	-	valproyl-dephosphoCoA	-	Rattus norvegicus

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Release 2023.1 (January 2023)