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Literature summary for 1.8.1.4 extracted from
- Purification and resolution of the pyruvate dehydrogenase complex (Escherichia coli) (1966), Methods Enzymol., 9, 247-265.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arsenite | in presence of NADH, inhibition is reversed by dithiols and less effectively by monothiols | Escherichia coli |  |
| Cd2+ | in presence of NADH, inhibition is reversed by dithiols and less effectively by monothiols | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
diyhdrolipoamide dehydrogenase component of the pyruvate dehydrogenase complex | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrolipoamide + NAD+ | - |
Escherichia coli | lipoamide + NADH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | 2 molecules of FAD per molecule of enzyme | Escherichia coli | |
| NAD+ | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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